Sheldon: Hello. Yes, you can help me, Dorothy Fitzpatrick. I'm interested in taking out a second mortgage. I'm nine years old. Why do you ask? That's called age discrimination, Dorothy, but I'm willing to let it slide. I'm glad you find me cute, but I'm deadly serious. I need funds to buy a computer. No, the house isn't in my name. I'm nine. We've established this. I do prepare the taxes for my parents, and if we tighten our belts, we'll have sufficient equity for the loan.

Sheldon: Per the student dress and grooming code, this boy's hair is too long. This boy's wearing sports attire outside a designated area. And this girl's blouse is diaphanous, which means I can see her brassiere.

Mary: You understand that some people are going to be intimidated by you, because of how smart you are?
Sheldon: Or maybe they'll recognize my intellect and make me their leader.

Mary: How about we lose the bow-tie?
Sheldon: Why?
Mary: Look around, honey. No of the other kids are wearing one.
Sheldon: Well, perhaps I'll start a fad.

Brenda Sparks: Well, I'm sorry, but you shouldn't be inferring there's something wrong with my Billy.
Meemaw: Darlin', there's no inferring. I've seen the boy sitting in the dirt eating his own belly button lint.

Mrs. Wolowitz: Howard, turn off that fakakta game and go to sleep.

Beverly Hofstadter: Leonard, dear, you should be in bed.

Adult Sheldon: A primary feature of quarks is that they're always bonded together, but in that moment, I felt like a neutrino, destined to be alone forever.
[Montage of young Leonard, Penny, Raj, Howard, Bernadette and Amy at that moment]
Adult Sheldon: Thankfully, I was wrong.

Mary: How's it going, baby?
Sheldon: I don't think anyone's showing up, not even Tam.
Mary: I'm here.
Sheldon: Yeah, but you're my mom. You live on the premises. At least Dr. Sturgis should be here any minute.
Mary: Shelly, I'm afraid Dr. Sturgis isn't coming this morning.
Sheldon: Why not?
Mary: He isn't feeling well.
Sheldon: Oh, dear. Should we send him a get well card?
Mary: I think that'd be terrific.

Meemaw: John?
Dr. John Sturgis: Hello.
Meemaw: What- What're you doing?
Dr. John Sturgis: I was doing tai chi and then I realized that I was continually being bombarded by subatomic particles and it behooves me, perhaps, to pay slightly closer attention to them. Maybe "chi" is the ancient Chinese word for the subatomic universe.
Meemaw: You're scaring me, John.
Dr. John Sturgis: Well, there's nothing to be scared of. Tomorrow, somebody will win the Nobel Prize about these particles not me. But I'm experiencing them firsthand [LAUGHS] which could be better.
Meemaw: Why don't you come down and experience them on the floor?
Dr. John Sturgis: I think I just felt a neutrino. [LAUGHING] You know, neutrinos are interesting. They never bond with anything, they're always alone. I think that one went right through my pants.
Meemaw: All right, why don't we go downstairs, and I'll fix us both a nice cup of hot tea and you can tell me all about it. Please?
Dr. John Sturgis: Okay. It was my dream to win the Nobel, and I'm not going to. I bet Sheldon will.
Meemaw: That'll be something.
Dr. John Sturgis: Yeah.