Mary: Sheldon, faith means believing in something you can't know for sure is real. And right now, I am struggling with that.
Sheldon: So you don't believe in God anymore?
Mary: That isn't something for you to worry about. I need to figure this out myself.
Sheldon: Can I help? Maybe I could provide a fresh perspective.
Mary: I don't think so, baby.
Sheldon: Did you know that if gravity were slightly more powerful, the universe would collapse into a ball?
Mary: I did not.
Sheldon: Also, if gravity were slightly less powerful, the universe would fly apart and there would be no stars or planets.
Mary: Where you going with this, Sheldon?
Sheldon: It's just that gravity is precisely as strong as it needs to be. And if the ratio of the electromagnetic force to the strong force wasn't one percent, life wouldn't exist. What are the odds that would happen all by itself?
Mary: Why are you trying to convince me to believe in God? You don't believe in God.
Sheldon: I don't, but the precision of the universe at least makes it logical to conclude there's a creator.
Mary: Baby, I appreciate what you're trying to do, but logic is here. And my problem is here.
Sheldon: Well, there are 5 billion people on this planet and you're the perfect mom for me. What are the odds of that?

Mary: You understand that some people are going to be intimidated by you, because of how smart you are?
Sheldon: Or maybe they'll recognize my intellect and make me their leader.

Rabbi Schneiderman: Can I ask how your parents feel about this?
Sheldon: Well, when I presented them with my plan, the words "over my dead body" were used.
Rabbi Schneiderman: [chuckles] I'm not surprised.
Sheldon: But they were similarly resistant when I wanted to get an ant farm and eventually they came around.
Rabbi Schneiderman: All right, here's what I'm gonna tell you to do. Read your Bible.
Sheldon: Already did, cover to cover.
Rabbi Schneiderman: Really?
Sheldon: Quiz me.
Rabbi Schneiderman: No, that's okay, I believe you. All right, my advice to you is to stay with the faith of your parents.
Sheldon: What else you got?
Rabbi Schneiderman: Okay. Then I'm gonna tell you to be your own man.
Sheldon: But I want to be a great scientist like Albert Einstein.
Rabbi Schneiderman: Sheldon, when your days are over, God will never ask you, "Why weren't you Einstein?" But he might ask you, "Why weren't you Sheldon?"

Adult Sheldon: A primary feature of quarks is that they're always bonded together, but in that moment, I felt like a neutrino, destined to be alone forever.
[Montage of young Leonard, Penny, Raj, Howard, Bernadette and Amy at that moment]
Adult Sheldon: Thankfully, I was wrong.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

George Jr.: Oh, dang! Nice!
Meemaw: It ain't my first egging. Whoo! Good one!
George Jr.: Ain't mine, neither.
Meemaw: [laughs] Here's for firing my grandson... jackass!

[As Sheldon finally retrieves the errant piece of hot dog meat from under the refrigerator:]
Sheldon: Whew. That was driving me crazy. Thank you for getting me into college.

[on the "Why Sheldon Cooper Should Go to College" tape:]
Sheldon: Sheldon Cooper, ready for college, ready to change the world.
George Sr.: Cut.
Sheldon: If that doesn't convince her, I don't know what her problem is.

[on the "Why Sheldon Cooper Should Go to College" tape:]
Dr. John Sturgis: Hi, Mary. I know this must be a hard decision for you. I can't tell you how to parent your child. I don't have children. But... I can tell you... that in all my years in academia, I've never seen a mind like Sheldon's. He's truly extraordinary. And if you let him come here, I promise we'll take good care of him.

[on the "Why Sheldon Cooper Should Go to College" tape:]
Mr. Givens: I'll chip in for gas money. I'll move him into his dorm. What-Whatever you need. Let's make it happen.