Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: All right, Tam. I decided I was gonna make you a real Texas dinner. Barbecued chicken and brisket.
Tam: Thank you.
Mary: Well, I figured you were probably tired of stuff wiggling around on your plate.

Mary: I pray that you protect Sheldon in all that he does.
Sheldon: What are you doing?
Mary: I'm praying for you.
Sheldon: She needs it more than I do.
Mary: You think I didn't start with her?

Mary: We're hiring a youth pastor.
Sheldon: Why?
Mary: To help get young kids excited about God.
Missy: The same God who lets babies get thrown in rivers?
Mary: What?
Sheldon: We covered Moses in Sunday school.
Mary: Oh. Well, that was Old Testament God. He gets more fun later.

Mary: When do we get to sit down with her and talk this through?
Georgie: Ah, yeah, here's the thing about that: she ain't real eager to meet y'all.
Mary: Why not?
Meemaw: Did you want to meet George's parents when he knocked you up?
Mary: I was not "knocked up," I was with child. And he's right there. [Georgie waves to Meemaw]

Mary: All right, what do you know?
George: Well, they're probably gonna have to pay some fine, and-and they're gonna need cash.
Mary: My son is gonna be in jail overnight?
George: What about your mother?
Mary: Oh, she's been there before.

Sheldon: Do you think Georgie got a tattoo in jail?
Mary: No.
Sheldon: Do you think Meemaw did?
Mary: Probably.

Sheldon: And then they laughed at me for not knowing something that they knew. Who does that?
Mary: You do.
Sheldon: Well, this is no time for a teachable moment. Your child is hurting.
Mary: Sorry. [taps Sheldon's shoulder] There, there.
Sheldon: I guess that'll do. Now, how about a hot beverage?

Sheldon: Mark my words, string theory is going to be the next big thing.
Mary: What does it do?
Sheldon: It explains the fundamental forces of the universe. How everything works, where everything came from.
Mary: I know where it all came from. [points to the heavens]
Sheldon: Mother, we're in the sky. Why are you pointing up?

Pilot: [v.o.] Sorry for the delay. We hope to be wheels up in about 20 minutes.
Sheldon: That's what he said 20 minutes ago.
Mary: Nothing we can do.
Sheldon: If we don't take off soon, we'll miss our connecting flight to Houston.
Mary: It's out of our hands. I'd tell you whose hands it's in, but you don't like that.

Mary: Well, Mandy said that you don't go to church that often, so... how Catholic could you be?
Audrey: That's a funny question coming from a woman who left her own church.
Mary: I went back. And... my granddaughter is not gonna be raised Catholic. She's gonna worship Jesus, not the Pope.
Audrey: We don't worship the Pope.
Mary: Well y'all sure bought him a pretty fancy car.

Pastor Jeff: And now George's loving wife Mary would like to say a few words. Mary.
Mary: Thank you, Pastor Jeff. Um... [clears throat] I met George in high school. Well, I was in high school. He was an older man with a motorcycle. [light laughter] I'd like to tell you he caught my eye, but actually it was the motorcycle. [laughter] [voice breaking] I'm sorry, I can't... do this. I am... so angry. [sighs] George and I had our ups and downs, but we were finally in such a good place, and then he... left. [crying] He left all of us. I- How could you do that? [Meemaw stands up] I am so mad at him. I'm mad at God, I'm mad at myself for not trying harder while he was here. [Meemaw goes up to Mary] This wasn't supposed to happen. [Mary sobs] [Meemaw hugs Mary] [Georgie hugs a crying Missy]

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: Oh, I know that you're hurting, and... I'm here for you, so... what do you need?
Meemaw: Great, take me drinking.
Mary: It is 3:30 in the afternoon.
Meemaw: Yes, it's called happy hour.
Mary: I have to make dinner.
Meemaw: Oh, fine. I'll just be sad and drunk by myself. Maybe I'll go home with the bartender.
Mary: Missy! I have to go out with your meemaw, but I'll be back later with KFC.