Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Mary: Oh, I know that you're hurting, and... I'm here for you, so... what do you need?
Meemaw: Great, take me drinking.
Mary: It is 3:30 in the afternoon.
Meemaw: Yes, it's called happy hour.
Mary: I have to make dinner.
Meemaw: Oh, fine. I'll just be sad and drunk by myself. Maybe I'll go home with the bartender.
Mary: Missy! I have to go out with your meemaw, but I'll be back later with KFC.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Sheldon: I smell ammonia. They must've done a thorough cleaning recently. I like that.

Adult Sheldon: That was the first time I held my father's hand. I wouldn't touch my brother's hand until seventeen years later, thanks to the invention of Purell.

Mary: You understand that some people are going to be intimidated by you, because of how smart you are?
Sheldon: Or maybe they'll recognize my intellect and make me their leader.