Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: All right, what do you know?
George: Well, they're probably gonna have to pay some fine, and-and they're gonna need cash.
Mary: My son is gonna be in jail overnight?
George: What about your mother?
Mary: Oh, she's been there before.

Sheldon: And then they laughed at me for not knowing something that they knew. Who does that?
Mary: You do.
Sheldon: Well, this is no time for a teachable moment. Your child is hurting.
Mary: Sorry. [taps Sheldon's shoulder] There, there.
Sheldon: I guess that'll do. Now, how about a hot beverage?

Mary: You smoke marijuana?
Sheldon: Mom!
Libby: No, ma'am.
Tam: Just say no. [Mary shoots him an unimpressed look]

George: Oh.
Georgie: Oh, what?
George: You didn't mention she was black.
Georgie: Was I supposed to?
George: No, 'course not.
Georgie: Then why bring it up?
George: It just wasn't what I was expecting.
Georgie: What were you expecting?
George: It's a big school. Why are you right here?
Georgie: They've got some books in there about Martin Luther King. Maybe you should go read one.

Mary: I don't want my little boy in some car with a teenager behind the wheel.
George: All high school kids drive.
Mary: Yeah? Well, I don't like it. Would you let me get in a car with a stranger when I was young?
Meemaw: Well, nobody ever asked you out, so it didn't really matter.