Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

George: You're not gonna make it in this school if you keep ratting people out.
Sheldon: But they were breaking the grooming codes and the dress codes. I saw one boy with a t-shirt that said... [leans in and whispers] "Bite me".
George: Yeah, that's terrible. [Sheldon nods]

Meemaw: What's all this about choking?
Georgie: Sheldon almost died this morning.
Meemaw: What?!
Georgie: Oh, yeah. Dad was shaking him upside down like a ketchup bottle.
Missy: It was great.

Adult Sheldon: In Texas, the Holy Trinity is God, football and barbeque, not necessarily in that order.

George: Damn it. I've had enough of this. Sheldon, get up.
Sheldon: What's the point?
George: We're going to Houston.
Sheldon: Really?
George: Yeah. You and me are gonna give those space monkeys a little talkin' to.
Adult Sheldon: I often found my father to be a strange and puzzling man, but at that moment, I never loved him more.

Mary: You're a good dad.
George: If I don't kill one of them before Sunday, I'm a good dad.

Adult Sheldon: Despite my explanation that I was embracing my inner Kirk, my mother had me make amends for all my misdeeds. Starting in the library, where I had to reshelve hundreds of books. Well, to be honest, that one was a hoot.

Sheldon: And this program will allow us to track our family finances, create a budget, and prepare tax documents.
George: That's impressive.
Sheldon: Would you like to know how much money you spend on beer annually?
George: No.
Mary: I would.
Sheldon: $936.
Mary: George!
Sheldon: If you switched to Hawaiian Punch, we could live in a bigger house.

Meemaw: Oh, Lord, I think I'm gonna wet myself.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Adult Sheldon: Existing in a world of predators isn't easy, but we prey have developed several natural defenses to help us survive. There's playing dead, warning calls, camouflage, and, last but certainly not least, good old-fashioned running away. A little screaming never hurts either.

Adult Sheldon: In that moment, I was so angry with her, I almost opened the jar.

Meemaw: This is delicious, but you were not kidding about the spice. I'm about to break a sweat here.
Dr. John Sturgis: Well, here's something you might find interesting. Spicy food is typically found in warmer climates because it induces sweating, which in turn, cools people off.
Meemaw: So what does the runny nose do for me?
Dr. John Sturgis: It allows me to, uh, gallantly offer you my handkerchief.
Meemaw: You are such a gentleman.
Dr. John Sturgis: When I was younger, I read a book on etiquette. That's how I know that if I ever have an audience at the Vatican, I should wear evening attire or a sack coat.
Meemaw: I don't know what a sack coat is, but I'm sure you'd look handsome in it.
Dr. John Sturgis: Thank you.

George: What's going on? You all right?
Mary: I'm not feeling great.
George: Is it a pregnant thing? 'Cause I got some good news on that. I got a decent raise.
Mary: It doesn't matter.
George: What do you mean it doesn't matter? We can pull this off now.
Mary: I lost the baby.
George: Oh.
Mary: You're probably relieved, huh?
George: Actually no. I love the first three. Fourth one's a charm, right?

Sheldon: Do you believe there's intelligent life in the universe?
Dr. John Sturgis: I have no doubt.
Sheldon: Why is that?
Dr. John Sturgis: The Drake Equation claims that there are at least 20 detectable civilizations in our Milky Way galaxy alone.
Sheldon: Interesting. My sister likes to say that I'm an alien.
Dr. John Sturgis: I've often been called that. Once by the praying mantis in my dream.
Sheldon: Maybe we are aliens.
Dr. John Sturgis: Perhaps. Or maybe people like you and me were the original inhabitants of Earth, and everyone else is from outer space.
Sheldon: Ooh, I like that better.