Adult Sheldon: [v.o.] We often regret the things we don't say. There's a lot of things I wish I had said to my dad while he was around. That I appreciated him. That I loved him. Which is why I'm grateful for the times I did tell him how I felt.
Sheldon: Tonight was fun.
George Sr.: Yeah? Why is that?
Sheldon: Dr. Sturgis was here. Everybody talked about science. It was nice.
George Sr.: It was.

[Sheldon is chuckling as he stares at a blank screen]
Missy: What are you doing?
Sheldon: Watching last week's Professor Proton in my mind.

Meemaw: Mind if I take a crack at catching the Road Runner?
Mary: What are you gonna do that I couldn't do?
Meemaw: Oh, a little trick I learned trying to get prairie dogs out of the hole. Of course we'd whack off their heads with a golf club. I'm not gonna do that to Sheldon.

Meemaw: Okay, here you go. I got you a shovel and a bucket and some gloves.
Sheldon: Did you check the gloves for spiders?
Meemaw: Is this my first day as Meemaw?

Brenda Sparks: What are you doing out here?
Billy Sparks: Playing with Sheldon.
Brenda Sparks: You're missing your party.
Billy Sparks: But I'm having fun.
Sheldon: Do not be alarmed, our mission is one of peace.
Brenda Sparks: I'm gonna go have a little chat with your mother.
Sheldon: Seems unlikely; my mother's on Vulcan.
Billy Sparks: My mom is on Valium.

Mary: How about we lose the bow-tie?
Sheldon: Why?
Mary: Look around, honey. No of the other kids are wearing one.
Sheldon: Well, perhaps I'll start a fad.

Adult Sheldon: I've often been accused of being stubborn and willful, but sometimes it works like gangbusters.

Meemaw: What's all this about choking?
George Jr.: Sheldon almost died this morning.
Meemaw: What?!
George Jr.: Oh, yeah. Dad was shaking him upside down like a ketchup bottle.
Missy: It was great.

Adult Sheldon: Whoever said the quickest way to a man's heart is through his stomach did not consider his tiny bladder.

Missy: Why don't you believe in God? [Sheldon raises his hand] Sheldon.
Sheldon: Because science explains the universe without the need of inventing a supernatural being.
Missy: But how do you know for sure He doesn't exist?
Sheldon: Ooh. [raises hand]
Missy: Stop that.
Sheldon: The burden of proof isn't on me. If I said there was an invisible monkey in the room with us, you shouldn't believe me just because you can't prove me wrong.

Meemaw: I could buy it for him, and then y'all could pay me back when you can.
George Sr.: Okay, Connie, now you're just insulting me.
Meemaw: Well, that was not my intention, but I'm glad to hear it.

Adult Sheldon: My new adult responsibilities began that night. Luckily, a cookbook is nothing more than a set of instructions. And if there's one thing I shine at, it's following instructions.

Dr. John Sturgis: Connie, I believe I have answers to all your questions.
Meemaw: Lay it on me.
Dr. John Sturgis: Time: the event begins at 6:00 p.m. The dress code is: business attire. Dinner will be served, but it's been suggested that we eat first, because the food is dreadful.
Meemaw: Good to know.
Dr. John Sturgis: And last but not least, a camelid is any member of the camelidae family, such as llamas, alpacas or vicuñas. You didn't ask that one, but, uh, it seemed like something you should know.

Sheldon: Why are you eating cereal for dinner?
Billy Sparks: I was hungry, and my parents are in their bedroom kissing.

George Sr.: The little Sparks girl?
Mary: You're kidding. She seems so sweet.
George Jr.: He says she slaps him around, takes his lunch money. She even put a tadpole down his shirt.
Meemaw: Poor kid. He tucks in those shirts.

Meemaw: So I saw a lawyer today.
Mary: Why?
Meemaw: I'm putting together my last will and testament.
George Sr.: We're gonna miss ya.
Mary: George.
Meemaw: Don't worry. I ain't leaving him squat.

Tam: Hey, I've been looking all over for you. Do you know how popular we are?
Sheldon: We?
Tam: Yeah. I put the word out I was helping you with the football stats. And since I'm Asian, they bought it.

Dr. Hodges: Now, what I thought would be fun to talk about today is what NASA's planning on doing beyond the Space Shuttle. Things like the first manned mission to Mars. Uh, yeah?
George Jr.: Did you see the movie Aliens?
Dr. Hodges: I did.
George Jr.: Did you think it was cool?
Dr. Hodges: Uh, sure, I enjoyed it.
George Jr.: Me, too.
Dr. Hodges: Football player, right?
George Jr.: Yes, sir.

Adult Sheldon: Existing in a world of predators isn't easy, but we prey have developed several natural defenses to help us survive. There's playing dead, warning calls, camouflage, and, last but certainly not least, good old-fashioned running away. A little screaming never hurts either.

Meemaw: Okay, I'm here. What's up?
George Sr.: Sheldon won't get out of bed, and I'm gonna be late for work. He's gonna be late for school.
Meemaw: So you want me to get him up and drive him?
George Sr.: Yeah.
Meemaw: I like it better when I just come eat your food and leave.