Mary: Can I help you?
FBI Agent #1: Sorry to bother you, ma'am. FBI. We're looking for a Sheldon Lee Cooper.
Mary: George!
George Sr.: I'm on the can.
Mary: Now!

George Sr.: What?
Mary: These gentlemen are with the FBI. They want to talk to Sheldon.
George Sr.: What? Y-You fellas must have made a mistake. Sheldon's nine.
FBI Agent #2: Well, someone living at this address recently called a mining operation in Canada and tried to buy uranium.
Mary: Okay, maybe it's not a mistake.

Mary: I think my husband's having a heart attack!
Nurse Robinson: I need an RRT and a crash cart.
Mary: Over here.
Nurse Robinson: Sir, are you having chest pains right now?
George Sr.: Yeah, a little bit.
Nurse Robinson: Any numbness or pain in your arms?
George Sr.: Maybe this one.
Nurse Robinson: Shortness of breath?
Mary: Enough questions. He's a fat, middle-aged man with chest pains. Do something!

Mary: Hi, Mom. Kids okay?
Meemaw: Yeah, they're fine. How's George?
Mary: I don't know. They're running tests.
Meemaw: Well, don't you worry about us. Everything's under control here.
Mary: Okay. I'll call you when I know more.
Meemaw: How you holdin' up?
Mary: I guess I'm okay.
Meemaw: Well, George is gonna pull through this, honey. I guarantee it.
Mary: Thanks, Mom. Thanks for bein' there.
Meemaw: You bet.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

George Sr.: You're actually cutting the crust off before you blend it?
Mary: I left it on his tuna sandwich yesterday, he said he could tell. Only drank half of it.

Mary: Now, the thing you have to understand is Shelly is incredibly bright. I mean, his IQ is right up there with Albert Einstein and that English wheelchair fella.

Mary: I got to tell you, I'm a little worried about my mother. She keeps betting on these football games, next thing you know, there's an Italian fella driving off with her pickup truck.

George Sr.: You think Sheldon's right?
Mary: About what?
George Sr.: The punting and the math.
Mary: I should think so. He's been doing our taxes since he's six years old. We never been audited.
George Sr.: That's true.
Mary: He even got us that nice refund last year.

Gerome: What the hell? Punt!
Mary: Statistically, they're better off going for it.
Gerome: Says who?
Mary: My little boy.

Gerome: Your little boy's a real genius.
Mary: Well, actually he is.

Mary: (to the guy who doubted Sheldon's tactics) Oh, booyah!

Mary: Georgie, turn that down!
George Jr.: What?
Mary: (turns off the music) And look at this room. You need to clean this mess up.
George Jr.: I'll get to it later.
Mary: No, you'll get to it now.
George Jr.: I don't feel like it.
Mary: Well, your feelings have nothing to do with it. And stop throwing that ball.
George Jr.: My room bothers you so much, you clean it.
Mary: That's it! You are grounded!

Mary: Shelly, time to get ready for bed.
Sheldon: But I'm not done.
Mary: Don't you sass me, too, young man. Brush your teeth and get to bed.

Tam: Good evening, Mrs. Cooper. Can I speak to Sheldon?
Mary: No, you can't speak to Sheldon. It's late. He's in bed.
Tam: Oh. I was hoping he might like to go to a party with me.
Mary: Has everyone lost their mind? He's a little boy, Tam! Good night!

Mary: I think he's feeling left out now that you and Sheldon are spending so much time together.
George Sr.: Are you kiddin' me? You're always saying to find something in common with Sheldon. And now that I have, you're telling me I'm ignoring Georgie?
Mary: I'm not saying that. I'm just reminding you that you got two sons.
George Sr.: I know. I also got a daughter I need to spend more time with.
Mary: You do. But I wouldn't worry about her. She's an angel.

Sheldon: Mom, can you take me to Radio Shack?
Mary: Not today, baby. I have to go food shopping and get dinner started.
Sheldon: But it's important.
Mary: Sorry. Maybe over the weekend.
Sheldon: But it won't take that long.
Mary: Sheldon, I said no.
Sheldon: But, Mom-
Mary: Not another word.

George Sr.: We can't keep putting up with this behavior. We need to ground him.
Mary: How? If you say "No playing outside," he says, "Thank you."

George Sr.: Oh, he's been in there quite a while.
Mary: Well, if the topic is science, he can be a real Chatty Patty.

Meemaw: Now, this is for your eyes only. You're not to share it with anybody.
George Sr.: I never I would never. [reading the note] You're a horrible person.
George Jr.: What'd it say?
Missy: I want to know what it said.
Sheldon: Me, too.
George Sr.: Just eat.
Mary: Can I read it? [reading the note] You are a horrible person.