Caltech Professor: You lost?
Sheldon: No. I'm exactly where I'm supposed to be.
["Walk of Life" by Dire Straits plays]

Georgie: I think the saddest part about it is just how sad it is.

Meemaw: I'm Sheldon Cooper's grandmother and, uh, I need to take him out of school today.
Diane: Sure. What's the reason?
Meemaw: His Aunt Emelda's not doing well, and has asked to see him 'fore she goes.
Diane: Oh, I am so sorry. Does she want to see his older brother also?
Meemaw: Nah. She doesn't like him as much.

Sheldon: Unbelievable. It's either cartoons or men in their underwear banging their heads together.
Ricky: You complain a lot.
Sheldon: Excuse me?
Ricky: Seriously, dude, you need to relax.
Sheldon: How can I relax? I'm being held captive in a bacterial playground.

Meemaw: You just need a new hobby.
Sheldon: Very well. What are yours?
Meemaw: Smoking, drinking and gambling. But we can find you something almost as fun.

Sheldon: We're going to jail.
Missy: Georgie's going to jail. I'm saying I was kidnapped.
Sheldon: That's a good plan. You and I were kidnapped.
Georgie: If I'm going to jail, we're all going to jail.

Meemaw: What's all this about choking?
Georgie: Sheldon almost died this morning.
Meemaw: What?!
Georgie: Oh, yeah. Dad was shaking him upside down like a ketchup bottle.
Missy: It was great.

Mary: Sheldon, who are you talking to?
Sheldon: Dorothy Fitzpatrick.
Mary: Who's Dorothy Fitzpatrick? Is she a new buddy from school?
Sheldon: She's the loan officer at The First National Bank of Medford.
Mary: Why are you talking to her?
Sheldon: Mom, can this wait? I'm trying to negotiate favorable terms. Hello, Dorothy? [Mary hangs up]

Sheldon: Dad, do you believe that fossils are millions of years old?
George: I guess. Why?
Sheldon: Well, Mom believes the world was only created 6,000 years ago.
George: Yeah. So?
Sheldon: Are these differences a sticking point in your marriage?
George: Not at all.
Sheldon: Why?
George: Simple. We never talk about it.
Sheldon: So you just avoid discussing topics you don't agree on?
George: At all costs.

Adult Sheldon: Jane Goodall had to go to Africa to study apes. I just had to go to dinner.

George: You don't always win in life, he needs to learn that.
Mary: I know, but these are big feelings for a little boy.
George: They're feelings everybody has. It's part of growing up.
Mary: I guess.
Sheldon: Poodle poop!
Meemaw: Okay. Somebody's got to teach this kid to swear, it's embarrassing.

Sheldon: Per the student dress and grooming code, this boy's hair is too long. This boy's wearing sports attire outside a designated area. And this girl's blouse is diaphanous, which means I can see her brassiere.

Sheldon: Why don't we ask somebody for directions?
Georgie: Because we're children in a car, genius.

Adult Sheldon: People often wonder why I chose to pursue a career in theoretical physics. I usually respond by saying I wanted to unravel the inner workings of the universe. But the real answer was I wanted to prove this nincompoop wrong.

Georgie: Are you dyin'?
Meemaw: We're all dyin', honey. From the second we're born, it's just a slip and slide into the darkness.
Georgie: Unless you get bit by a vampire.
Meemaw: Well, now that goes without saying.