Mary: [praying] Lord, I am trying my best. Please help me with this situation. Amen. [sees a "love thy neighbor" stitching on a pillow] I meant fix him, not me.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Meemaw: So what's goin' on?
Missy: I think I have a boyfriend.
Meemaw: Wow.
Missy: But you cannot tell Mom.
Meemaw: Oh, of course... I love not telling your mother stuff.

Meemaw: What's up?
Missy: Can I talk to you about serious woman stuff?
Meemaw: Of course. Is this a... iced tea conversation or a hot tea conversation?
Missy: Definitely hot.
Meemaw: Uh-oh.

Sheldon: There's no telling who could buy that house! What if they have dogs? What if they have birds? What if they have both and the birds learned to bark like dogs?
Mary: Sheldon, you're gettin' yourself all worked up.
Sheldon: For good reason... that house is six feet away from my bedroom window. Who knows what kind of smells could jump the gap? Uh, cigarette smoke, a scented candle, a durian?
Mary: What's a durian?
Sheldon: A vile-smelling fruit of the genus Durio.
Mary: When did you smell that?
Sheldon: I haven't, and I'd like to keep it that way.
Mary: It might be nice. It might be a family with kids your age.
Sheldon: I already live with a kid my age... not a fan!