Meemaw: Thanks for inviting John to dinner tonight.
Mary: Oh, my pleasure.
Meemaw: I've been a little bit worried about him. You know, with what happened last time.
Mary: At least he didn't seem unstable when I talked to him.
Meemaw: The man has a doctorate in science, and he's filling people's grocery bags.
Mary: He actually did a really nice job. He put the heavy things on the bottom. He kept the cold things together.
Meemaw: Mary.
Mary: Well, they don't always do that.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: [v.o.] We often regret the things we don't say. There's a lot of things I wish I had said to my dad while he was around. That I appreciated him. That I loved him. Which is why I'm grateful for the times I did tell him how I felt.
Sheldon: Tonight was fun.
George Sr.: Yeah? Why is that?
Sheldon: Dr. Sturgis was here. Everybody talked about science. It was nice.
George Sr.: It was.

President Hagemeyer: Sheldon, Dr. Sturgis quit right before the semester started. He left me in the lurch.
Sheldon: And this is your chance to be the bigger person.
President Hagemeyer: I don't want to be the bigger person. I'll be the small, petty person. That's way more fun.
Sheldon: Please? It would make me really happy if he came back. And you said yourself my happiness is important to the university.
President Hagemeyer: Are you trying to manipulate me?
Sheldon: Hey, being small and petty is fun.

[fantasy:]
Dr. John Sturgis: [Southern accent] To us, it'd be as normal as boots on a cowboy.
George Jr.: That is wild.
Missy: Dr. Sturgis is correct. If indeed we grew up in another universe, our sense of normality would be formed by that universe.
George Sr.: That's enough. There are no other universes. The Bible tells us God created the Earth, not the Earths.
Mary: Ugh, why did I have to marry a preacher?
George Sr.: Because it was God's will to bless us with union.
Mary: I hope it's his plan that I hit the clubs tonight, 'cause that's gonna happen. [laughs]
Sheldon: Why am I the only normal one in this family?
Missy: If you're the only normal one, statistically speaking, you're abnormal.
George Jr.: [chuckles] Freak.