Sheldon: Washcloth?
Mary: Washcloth.
Sheldon: Soap?
Mary: Soap.
Sheldon: Shampoo?
Mary: Shampoo.
Sheldon: Baby shampoo?
Mary: Does E equal MC squared?
Sheldon: Love you.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Meemaw: Look, you haven't even gotten to the worst part of it yet. They're gonna leave home. They're gonna move to another city.
Mary: Oh, Lord.
Meemaw: They're gonna tell you their loser boyfriend has knocked them up. Just to be clear, that would be you.
Mary: Sorry.
Meemaw: Turned my hair gray overnight.
Mary: I said sorry. Clearly, you're not in the mood to help.
Meemaw: Listen, it's hard being a parent, but if you do it right, they don't need you anymore.
Mary: Well, I don't like that. I get it, but I just don't like it.
Meemaw: Well, I'd point out, you'll always have your husband, but you want me to be "helpful".

Sheldon: Well, that's what I heard. And if Hawking doesn't let it stop him, then I can't let this cast stop me.
Missy: Great. Go back to sleep.
Sheldon: I will, and I'll do it all by myself. [sings] Soft kitty, warm kitty
Missy: Oh, my God.
Sheldon: Little ball of fur Happy kitty, sleepy kitty, purr Purr, purr.

George Jr.: "Have a great summer. Georgie". Normally I'd write, "Have a bitchin' summer", but I figured you wouldn't like that.
Sheldon: I wouldn't.