Meemaw: Smart.
Mary: Thank you.
Meemaw: You're good at lying. You should do it more often.
Mary: I like your earrings.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: I was just letting you know that if you were having any problems you could come to me with them.
Sheldon: You think I have mental problems?
Mary: Well, not problems. I'm just worried about your future, and when I see you moving subatomic particles around in the air, that makes-
Sheldon: Subatomic particles are real! You talk to an invisible man in the sky who grants wishes. If anyone's mental, it's you.

Sheldon: [to Mary] I am behaving no differently than I ever have. Why are you suddenly so worried about me?
Dr. Goetsch: That is a valid question. Has anything changed recently?
Sheldon: Maybe it's hormonal. When does menopause typically begin?
Mary: It is not my hormones.
Sheldon: Well, it certainly isn't mine. I'm showing no signs of puberty.

Sheldon: Mother?
Mary: Yes?
Sheldon: Is it okay if I use a knife to butter my toast, or are you worried I'll do something crazy with it?
Mary: You can butter your own toast.
Sheldon: Oh, good. You see the toast, too. I was afraid I was imagining it.