Mary: If you want, I can ask Missy to hang out with him, make sure things go okay.
Brenda Sparks: Absolutely not.
Mary: Why?
Brenda Sparks: That girl is cute and sassy, and has a real chance at being popular. Do not take that from her. Or me.
Mary: Popularity isn't that important.
Brenda Sparks: It is the most important. Look at us. I'm miserable. You're always worried about something. I'd like one girl around here to win.
Mary: I'm not always worried.
Brenda Sparks: It's Sheldon's first day of college, and you're not freaking out?
Mary: It's on my mind.
Brenda Sparks: Mm.
Mary: But he's been looking forward to this for a long time. I'm sure he's having a wonderful day.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Professor Ericson: So we learned that the theory of knowledge poses some very serious problems.
Sheldon: [enters] Excuse me, Professor Ericson. I've done a little reading since last we spoke, and I'm prepared to show you that everything we know about science is true.
Professor Ericson: Well, I am all ears.
Sheldon: You said I couldn't truly know anything, but there is one thing that I do know. If I question, I must think; If I think, I must exist. Cogito, ergo sum: I think, therefore I am.
Professor Ericson: You're right.
Sheldon: You're darn right I'm right.
Professor Ericson: Guys, g-give it up for Sheldon. [applause] Now for a job well done... here is a flower full of sweet nectar.
Sheldon: Why would I want that?
Professor Ericson: Because you're a butterfly and this is just your dream.
Sheldon: I'm not a butterfly.
Professor Ericson: Are you sure? [laughs]
[Sheldon wakes up:]
Sheldon: It was a dream. Oh, no. [camera pans out] Help! I'm a butterfly! Nothing I know is real! Everything is a dream! Missy, help! [Missy holds a fly swatter] No!
[Sheldon wakes up:]
Sheldon: Missy, am I awake or is this a dream?
Missy: Shut up, dingus.
Sheldon: Okay, I'm awake.

Sheldon: I stopped at the library today and picked up books on epistemology, Descartes's dream argument and the foundations of scientific logic. Do you know what she's going to do?
Meemaw: Rue the day?
Sheldon: The day, the night. If it's rue-able, she's going to rue it.

Mary: Hey, Brenda.
Brenda Sparks: She didn't want you to walk her in?
Mary: No. How about Billy?
Brenda Sparks: Oh, I walked him in. Found his homeroom. Explained that "homeroom" is different than his room at home. Still not sure he gets it.
Mary: Tough day.
Brenda Sparks: Yeah.
Mary: You want to get some coffee?
Brenda Sparks: I was thinking vodka, but coffee will do.