Missy: "I hope your arm gets better soon. XO, Missy". See? Nothing mean.
Sheldon: Thank you.
Adult Sheldon: My sister could have a big heart. If only that were true of her brain.
Sheldon: That's the wrong "your".
Missy: What are you talking about?
Sheldon: It's supposed to be Y-O-U-R. What you wrote means, "I hope you are arm gets better".
Missy: Oh.
Sheldon: You defaced my body with a grammatical error.
Missy: I guess that's your problem. Y-O-U-R.

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Dr. Sandra Thorpe: Have you always been that way?
Missy: I guess so. I think when you're on your own a lot, you get good at seeing that kind of stuff.
Dr. Sandra Thorpe: Really?
Missy: My dad does football with my older brother, so they're like a team. And my mom and meemaw spend all their time fussing over Sheldon, so they're like a team, too.
Dr. Sandra Thorpe: So no one's on your team?
Missy: Nope. It's just me.

Sheldon: Well, that's what I heard. And if Hawking doesn't let it stop him, then I can't let this cast stop me.
Missy: Great. Go back to sleep.
Sheldon: I will, and I'll do it all by myself. [sings] Soft kitty, warm kitty
Missy: Oh, my God.
Sheldon: Little ball of fur Happy kitty, sleepy kitty, purr Purr, purr.

Georgie: "Have a great summer. Georgie". Normally I'd write, "Have a bitchin' summer", but I figured you wouldn't like that.
Sheldon: I wouldn't.

Georgie: What do you want?
Sheldon: I was hoping you could help me build up my leg muscles to increase my speed.
Georgie: If you don't want people chasing you, be less annoying.