George Jr.: If the point is you made some bad decisions and turned out fine, then why you being so hard on me?
Mary: Because some decisions you cannot walk away from and they will affect the rest of your life.
George Jr.: If you're talkin' about Jana getting pregnant, she ain't gonna.
Mary: That is what I thought, and the next thing I know, I'm at the courthouse gettin' married.
George Jr.: You got married because you were pregnant?
Mary: Yes.
George Jr.: So, I was a mistake?
Mary: No! No! You are a blessin'. The mistake was lyin' to my parents, so that I could spend the night at your dad's house. And, you know, tequila.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Sheldon: Dad, the university offered to pay for us to go to California! They're even putting us up in a hotel.
George Sr.: You're kidding.
Missy: We're going to California?
Sheldon: No, just me and Dad.
Missy: That's fair. I'm so happy for you.
Adult Sheldon: Sometimes sarcasm was laid on so thick even I could detect it.
Sheldon: Thanks!
Adult Sheldon: This was not one of those times.

Sheldon: Dad, good news. Airline tickets to California are more affordable than you think.
George Sr.: Sheldon, we're not going.
Mary: What's all this about?
Sheldon: Stephen Hawking is giving a lecture at Caltech. If we leave on Wednesday and are willing to make four layovers, in Boise, Denver, Albuquerque and Fargo, we can get there for only $95 each.

George Sr.: I have a job. I can't just leave in the middle of the week.
Sheldon: Well, then what about Mom?
Mary: Sorry, Shelly, we're not in a position to do this.
Sheldon: But Stephen Hawking's my hero. Imagine if you got a chance to see Jesus or Dad got to meet the man who invented beer.