Mary: Baby, there's something I need to tell you. Dr. Sturgis is not in the kind of hospital you think he is.
Sheldon: What kind of hospital is he in?
Mary: The psychiatric kind.
Sheldon: Why? What's going on?
Mary: He was having some issues, but he's getting the help he needs, and I'm sure he's gonna be fine.
Sheldon: And you think since he and I are both gifted, I'm going to end up like him?
Mary: Well, it it crossed my mind. Sheldon, you're my baby. It is my job to worry about you. I can't help it.
Sheldon: I'm sorry I cause you so much concern.
Mary: I'm not. Oh. [hugging Sheldon]
Dr. Goetsch: See how valuable a little communication can be?
Mary: You do not take credit for this.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: I was just letting you know that if you were having any problems you could come to me with them.
Sheldon: You think I have mental problems?
Mary: Well, not problems. I'm just worried about your future, and when I see you moving subatomic particles around in the air, that makes-
Sheldon: Subatomic particles are real! You talk to an invisible man in the sky who grants wishes. If anyone's mental, it's you.

Sheldon: [to Mary] I am behaving no differently than I ever have. Why are you suddenly so worried about me?
Dr. Goetsch: That is a valid question. Has anything changed recently?
Sheldon: Maybe it's hormonal. When does menopause typically begin?
Mary: It is not my hormones.
Sheldon: Well, it certainly isn't mine. I'm showing no signs of puberty.

Sheldon: Mother?
Mary: Yes?
Sheldon: Is it okay if I use a knife to butter my toast, or are you worried I'll do something crazy with it?
Mary: You can butter your own toast.
Sheldon: Oh, good. You see the toast, too. I was afraid I was imagining it.