Nora: Oh. Looks like you bit your cheek.
Sheldon: How do you know it's not scurvy?
Nora: Because you're not a pirate.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Ms. MacElroy: Now, can anyone tell me why Melville shifts the narrative voice from Ishmael to Ahab? [Ms. MacElroy waits for somebody else to raise their hand] Sheldon.
Sheldon: I have a tummyache. I'd like to see the nurse.
Derek: A "tummyache"?
Sheldon: Yes, Derek, I have a tummy and it aches. Ergo, tummyache.
Derek: Ergo?
Sheldon: It's Latin, Derek.
Ms. MacElroy: Go to the nurse.
Sheldon: And to answer your question, the shifting point of view grants the reader a broader perspective of events than typically allowed by first-person narration.
Ms. MacElroy: Where were we?
Sheldon: And "ergo" is Latin for "hence," Derek.

Sheldon: Unbelievable. It's either cartoons or men in their underwear banging their heads together.
Ricky: You complain a lot.
Sheldon: Excuse me?
Ricky: Seriously, dude, you need to relax.
Sheldon: How can I relax? I'm being held captive in a bacterial playground.

George Jr.: How come when I'm sick it's no big deal, but when Sheldon gets sick you act like it's the end of the world?
Mary: Because he's a fragile little boy and you're gettin' to be a big, strong man.
George Jr.: That's true. Puberty has done right by me.