Mary: I don't like you making me out to be the bad guy just 'cause I won't let my daughter do whatever she wants.
Meemaw: I gave you a lot of freedom, you turned out okay.
Mary: You didn't give me freedom. You were never around.
Meemaw: Is that so?
Mary: I guarantee I made supper for Charlene and Edward more times than you ever did. I basically raised 'em.
Meemaw: You think I was out dancing? I was out working two jobs so your daddy could lose all our money on that damn chain of Fotomats!
Mary: It wasn't Daddy's fault that those little things blew over every time there was a storm.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: I didn't realize until years later that my father was only asking questions about lightning and thunder to cheer me up. In fact, he would often pretend to be dumb just to make me feel better.

Adult Sheldon: I never did get to see a launch in person, but that was the best trip I ever had. I wish I had told my father while he was alive.

Mary: Wait, Georgie. Where's your bag?
George Jr.: Don't need one. Got my toothbrush right here.
Mary: What about clothes? A change of underwear?
George Jr.: Got it.
Mary: Georgie, you're gonna be gone for two days.
George Jr.: I'll turn them inside out.