Mary: So, then, was there no big blowup when he left?
Brenda Sparks: Not really.
Mary: Well, what happened?
Brenda Sparks: Let's see... We used to be happy. Little by little, we weren't. Then there was bickering, then there was silence, and then... it was over.
Mary: I mean... all couples bicker, right?
Meemaw: You worried about you and George?
Mary: Of course.
Brenda Sparks: I'm sure you guys will be fine.
Meemaw: And if it doesn't work out, I'd be happy to introduce you to Butt Crack Bob over here. [laughs]

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: Like a virus, heartbreak can also spread. Once it does, it's hard to contain. In some cases you can try to reboot and start over. But it makes you appreciate those early days, when your hard drive was clean... and the world was full of possibility.

Meemaw: Well, let's get into it. What happened? If it's another woman, she's a tramp, and you're way prettier.
Brenda Sparks: No. Although sometimes I wish there was. Then I'd have someone to be mad at other than myself.
Meemaw: And here I thought this one was gonna be the sad sack.
Mary: Mom, that is enough.
Meemaw: Oh, there's my little killjoy. [both laughing]

Adult Sheldon: As long as humans have been on Earth, they've had to contend with viruses. And as long as I've been on Earth, I've come up with fun ways to avoid them.
[flashback:]
Dr. Linkletter: I've heard so much about you. [offers hand]
Sheldon: Apparently not how I feel about shaking hands.
Adult Sheldon: I wear personal protective equipment...
[flashback to Sheldon putting on mittens at the dinner table]
[flashback to Sheldon wearing an astronaut suit in his bubble:]
Mary: You come here right this instant.
Adult Sheldon: ...and I was social distancing before it was cool. But in the early '90s, a new type of virus became prevalent. One that no amount of hand-washing could stop. A computer virus.
Sheldon: Oh, no.
Adult Sheldon: But let's back up and begin this story in a simpler time, before an insidious infection had upended my life.