Missy: Will this make me look older?
Meemaw: Definitely.
Missy: But not like you older, right?
Meemaw: Right.

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Billy Sparks: Who's Melissa?
Missy: Me.
Billy Sparks: Then who's Missy?
Missy: "Missy" is short for "Melissa." Like how "Billy" is short for "William."
Billy Sparks: I don't understand.
Missy: You know how your real name is William?
Billy Sparks: I'm Billy.
Sheldon: No, we call you Billy, but your real name is William.
Billy Sparks: But my underpants say "Billy" in them. Mom, is my name William?
Brenda Sparks: [sighs] Yeah.
Billy Sparks: Then whose underpants am I wearing?

Mary: Missy, don't forget that you have to pick out a present for that birthday next week.
Missy: Mom, it's "Melissa" now.
Mary: [to Brenda] Middle school.

Pastor Jeff: Two months! Two months till this baby comes! There's so much I thought I was gonna do in my life.
George Sr.: I'm sure you've done plenty.
Pastor Jeff: Nothing cool. Look at you. You played football and rode a motorcycle.
George Sr.: Well, you save people's souls. That's neat, right?
Pastor Jeff: Oh, it's neat as neat can be, but you know that's not what I'm talking about.
George Sr.: [sighs] Look, being a dad doesn't mean your life is over. It just means it's different. Instead of playing football, I get to coach it now. I mean, high school football. Not college like I'd hoped. I-Instead of a motorcycle, I drive a truck. To work every single day. To pay the bills. [sighs] Oh. Endless bills. What happened to my life?
Pastor Jeff: Orange wedge?