Missy: You know what I like about you, Sheldon? You're incredibly smart, but you're also really dumb.
Sheldon: Why would you say that?
Missy: You think people are gonna come here to hang out with you?
Sheldon: Yes.
Missy: To hear about science?
Sheldon: Yes.
Missy: On the radio?
Sheldon: Yes.
Missy: At 5:00 in the morning?
Sheldon: Yes.
Missy: And you're asking me why you're dumb?
Sheldon: Well, I happen to have a little more faith in the curiosity of my fellows.
Missy: See, you sound smart, but you're still dumb.

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Missy: Eat dirt. Eat it.
Meemaw: Kick his ass!
Missy: Does it taste good? Huh?
Dale: Yeah, listen to your meemaw. Kick his ass!
Missy: You gonna cry? Huh? Do it. Cry.
Mary: Do something. Break it up.
George Sr.: H-Hang on. She's winning.
Mary: Missy! Missy Cooper, you stop beating up that boy!
Meemaw: Punch him in the nuts!

Missy: Someone's Underoos are in a knot.
Sheldon: My Underoos are fitting just fine, thank you.
Missy: Then why is there a stick up your butt?
Sheldon: Stop making inquiries about my bottom.
Missy: But I enjoy it.

Adult Sheldon: A primary feature of quarks is that they're always bonded together, but in that moment, I felt like a neutrino, destined to be alone forever.
[Montage of young Leonard, Penny, Raj, Howard, Bernadette and Amy at that moment]
Adult Sheldon: Thankfully, I was wrong.

Meemaw: John?
Dr. John Sturgis: Hello.
Meemaw: What- What're you doing?
Dr. John Sturgis: I was doing tai chi and then I realized that I was continually being bombarded by subatomic particles and it behooves me, perhaps, to pay slightly closer attention to them. Maybe "chi" is the ancient Chinese word for the subatomic universe.
Meemaw: You're scaring me, John.
Dr. John Sturgis: Well, there's nothing to be scared of. Tomorrow, somebody will win the Nobel Prize about these particles not me. But I'm experiencing them firsthand [LAUGHS] which could be better.
Meemaw: Why don't you come down and experience them on the floor?
Dr. John Sturgis: I think I just felt a neutrino. [LAUGHING] You know, neutrinos are interesting. They never bond with anything, they're always alone. I think that one went right through my pants.
Meemaw: All right, why don't we go downstairs, and I'll fix us both a nice cup of hot tea and you can tell me all about it. Please?
Dr. John Sturgis: Okay. It was my dream to win the Nobel, and I'm not going to. I bet Sheldon will.
Meemaw: That'll be something.
Dr. John Sturgis: Yeah.

George Jr.: A bill? Really?
George Sr.: Room and board, buddy.
George Jr.: $50 a month for food?
George Sr.: The way you eat, I should've gone $50 a week.
George Jr.: Laundry services?
George Sr.: Your poor mother has to touch your underwear.
George Jr.: What's the $10 a month "peema" charge?
George Sr.: Oh, P-I-M-A, that's a "Pain in My Ass" tax. My way of getting compensated for you taking years off my life.