[After Sheldon storms off with his upgraded computer:]
Jim: He gonna be okay?
George: Oh. Tonight, sure. Big picture? [shrugs]
Adult Sheldon: I've got a hot wife and a Nobel Prize. I turned out fine.

Adult Sheldon: I didn't realize until years later that my father was only asking questions about lightning and thunder to cheer me up. In fact, he would often pretend to be dumb just to make me feel better.

Adult Sheldon: My father didn't always get the credit he deserved. The advice he gave me actually worked out pretty well. Of course, I never told him.
George: Talked to Billy.
Missy: Why would you do that?
George: No, it was good.
Missy: Stay out of my life.
Adult Sheldon: He may not have been the world's greatest dad. But maybe we weren't the world's greatest kids.

Adult Sheldon: Ignoring things that irritate me isn't my strong suit. Obsessively fixating on them, now that's what gets me out of bed in the morning.

Georgie: It's for my daughter. Mom baptized her in the kitchen sink, and Mandy's mom did it in a Catholic church.
Sheldon: Sure. Baptists versus Catholics. Much blood was shed over that in the 1500s.

Mary: [on the phone] Hi, Pastor Jeff. Can you come over right now? I need you to save someone's soul.
[Cut to Mary opening the front door to Pastor Jeff, who is holding his bible:]
Pastor Jeff: Whose soul needs saving? Is it Sheldon? I've been waiting for this.
Mary: No. We're still praying for him. Come in, we don't have much time.

Mary: We have to say something.
George: Or we mind our business.
Mary: It is a sin, George.
George: And like a good Christian, I choose to forgive them.