Mary: Doesn't look like a bug bite.
Missy: It's probably a pimple.
Sheldon: It's not, I don't get those.
[fantasy: A.V. continues to address the camera from his chair, while Pus is blowing up a balloon while seated on a stool:]
A.V.: As you might expect, we pimples are not very fond of popping things, but I was about to burst this young man's bubble. [Pus pops the balloon]
[reality:]
Missy: Oh, yeah, that's a zit.
Sheldon: No, it's not. My hygiene is impeccable.
Missy: Zit.
Mary: Everybody gets 'em sooner or later, baby.
Sheldon: I'm not everybody.
[fantasy:]
A.V.: No one is ever happy to see me. My therapist says that's their problem, not mine. [Pus rolls his eyes] But, honestly, it hurts. [Pus makes a mocking gesture] Pus? This is supposed to be a safe space. [Pus continues mocking A.V.]

Mary: Let's say grace.
Sheldon: Hang on, safety first. [puts mittens on]
George Jr.: When are you gonna get over that?
Sheldon: I would think recent events would make you value protection.
Mary: Enough.

Ms. MacElroy: Now, can anyone tell me why Melville shifts the narrative voice from Ishmael to Ahab? [Ms. MacElroy waits for somebody else to raise their hand] Sheldon.
Sheldon: I have a tummyache. I'd like to see the nurse.
Derek: A "tummyache"?
Sheldon: Yes, Derek, I have a tummy and it aches. Ergo, tummyache.
Derek: Ergo?
Sheldon: It's Latin, Derek.
Ms. MacElroy: Go to the nurse.
Sheldon: And to answer your question, the shifting point of view grants the reader a broader perspective of events than typically allowed by first-person narration.
Ms. MacElroy: Where were we?
Sheldon: And "ergo" is Latin for "hence," Derek.

Missy: What's it like to not believe in God?
Sheldon: It's great. Big fan.
Missy: Are you ever afraid you're wrong?
Sheldon: About religion? Never. About other things? Also never.

Adult Sheldon: [hushed] This is why the only bar I frequent is the Genius Bar at the Apple Store.

President Hagemeyer: Okay, so, what's the problem?
Sheldon: I wanted to talk with Dr. Linkletter about puberty.
Dr. Linkletter: And I wanted to avoid litigation.

Missy: Sheldon, there has to be stuff you're excited to do.
Sheldon: Of course. Getting my PhD, winning the Nobel Prize, getting to meet Professor Proton, working with Stephen Hawking.
Missy: Okay, so, when you start to get upset, focus on that stuff.
Sheldon: But... what if I grow up and none of those things ever happen?
Missy: All you can do is try and find out.
Sheldon: Those are the fundamentals of the scientific method.
Missy: No doy.