Alex Trebek: [on TV] Animated films. Frog anatomy. The Bible.
Missy: Why are you watching Jeopardy?
George: Sheldon's not the only one who likes to learn stuff.
Missy: You don't know where the remote is.
George: It's right here. It's just out of batteries.
Missy: Want me to get some?
George: A can of beer while you're up.

George: And Sheldon's fine. You know what he's like. If someone took him, I'm sure they'll bring him right back.

Sheldon: There's going to be a lecture on carbon dating at the Natural Science Museum on Saturday. Who would like to take me?
George: You know what? I'd be happy to.
Meemaw: What happened to helping me at my yard sale?
George: Ooh, is that this Saturday? I'm sorry. I'm taking him to a lecture on, uh what is it? Carbonation?
Sheldon: Carbon dating. A method of determining the age of artifacts and fossils.
George: Hey, we could use that to figure out how old your grandma is.
Sheldon: That won't work. You can't carbon-date something that's alive.
George: Well, then, we'll just chop her down and count the rings.
Meemaw: Oh, George, did my "lump of clay" remark strike a nerve?
George: A little.

Georgie: A bill? Really?
George: Room and board, buddy.
Georgie: $50 a month for food?
George: The way you eat, I should've gone $50 a week.
Georgie: Laundry services?
George: Your poor mother has to touch your underwear.
Georgie: What's the $10 a month "peema" charge?
George: Oh, P-I-M-A, that's a "Pain in My Ass" tax. My way of getting compensated for you taking years off my life.

Mary: You are unbelievable. It is bad enough for you to do all this stuff, but then to drag Georgie down into your den of sin.
Meemaw: Oh, please, it's not a den of sin. Although that is a great name. Den of Sin. That would get some butts in seats. [Mary exclaims]

Pastor Jeff: Hey, Mary. Quick question. Why can I see you through my newsletter?
Mary: Oh, sorry, I had to remove one of the ads.
Pastor Jeff: Was there anything important on the other side?
Mary: Just Peg's recipe for her grape salad.
Pastor Jeff: With the mayonnaise and the pretzels. Barf.

Mary: [prays] Please watch over Missy and Sheldon and especially Georgie. And please don't let my failings as a mother get in the way of Your plans for their lives. Amen. [gasps] Hey, baby. What's wrong?
Sheldon: Is it that obvious?
Mary: Well, you are outside, where birds live.
Sheldon: True. I'll make it quick. I'm experiencing what the Germans call weltschmerz.
Mary: Uh-huh. And what do Americans call it?
Sheldon: The pain of the world.
Mary: Sounds more fun in German.
Sheldon: Most things do.