Meemaw: I just hate to see him give up like this.
Missy: Who you talking about?
Meemaw: Dr. Sturgis.
Missy: What'd he give up?
Meemaw: Science. He's working at a grocery store.
Missy: At least he didn't give up being weird.
Mary: He is also coming over for dinner, so behave yourself.
Missy: I can behave at school or I can behave at home. I can't do both.

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Missy: Eat dirt. Eat it.
Meemaw: Kick his ass!
Missy: Does it taste good? Huh?
Dale: Yeah, listen to your meemaw. Kick his ass!
Missy: You gonna cry? Huh? Do it. Cry.
Mary: Do something. Break it up.
George Sr.: H-Hang on. She's winning.
Mary: Missy! Missy Cooper, you stop beating up that boy!
Meemaw: Punch him in the nuts!

Missy: Someone's Underoos are in a knot.
Sheldon: My Underoos are fitting just fine, thank you.
Missy: Then why is there a stick up your butt?
Sheldon: Stop making inquiries about my bottom.
Missy: But I enjoy it.

Adult Sheldon: [v.o.] We often regret the things we don't say. There's a lot of things I wish I had said to my dad while he was around. That I appreciated him. That I loved him. Which is why I'm grateful for the times I did tell him how I felt.
Sheldon: Tonight was fun.
George Sr.: Yeah? Why is that?
Sheldon: Dr. Sturgis was here. Everybody talked about science. It was nice.
George Sr.: It was.

President Hagemeyer: Sheldon, Dr. Sturgis quit right before the semester started. He left me in the lurch.
Sheldon: And this is your chance to be the bigger person.
President Hagemeyer: I don't want to be the bigger person. I'll be the small, petty person. That's way more fun.
Sheldon: Please? It would make me really happy if he came back. And you said yourself my happiness is important to the university.
President Hagemeyer: Are you trying to manipulate me?
Sheldon: Hey, being small and petty is fun.

[fantasy:]
Dr. John Sturgis: [Southern accent] To us, it'd be as normal as boots on a cowboy.
George Jr.: That is wild.
Missy: Dr. Sturgis is correct. If indeed we grew up in another universe, our sense of normality would be formed by that universe.
George Sr.: That's enough. There are no other universes. The Bible tells us God created the Earth, not the Earths.
Mary: Ugh, why did I have to marry a preacher?
George Sr.: Because it was God's will to bless us with union.
Mary: I hope it's his plan that I hit the clubs tonight, 'cause that's gonna happen. [laughs]
Sheldon: Why am I the only normal one in this family?
Missy: If you're the only normal one, statistically speaking, you're abnormal.
George Jr.: [chuckles] Freak.