George Sr.: Uh, hey, Billy. I thought you were playing computer games with Sheldon.
Billy Sparks: I got bored so I came out here.
George Sr.: Well, you want me to go get him?
Billy Sparks: No, I'm fine by myself.
Coach Wilkins: Where's my serving bowl?
George Sr.: Uh, hey, Wayne, this is Billy.
Coach Wilkins: Hey.
Billy Sparks: Hello.
George Sr.: His mama's the one Mary took out tonight.
Coach Wilkins: Oh, right.
George Sr.: Billy, you just make yourself comfortable, watch whatever you want and help yourself to the fridge.
Billy Sparks: Thank you.
Coach Wilkins: You can't just leave this kid by himself.
George Sr.: Why not?
Coach Wilkins: His father's gone. He's lonely.
George Sr.: [quietly] Well, what do you want me to do, invite him to play poker? [normal voice] Hey, Billy, why don't you come hang with us?

George Sr.: And Sheldon's fine. You know what he's like. If someone took him, I'm sure they'll bring him right back.

Sheldon: Dad, do you believe that fossils are millions of years old?
George Sr.: I guess. Why?
Sheldon: Well, Mom believes the world was only created 6,000 years ago.
George Sr.: Yeah. So?
Sheldon: Are these differences a sticking point in your marriage?
George Sr.: Not at all.
Sheldon: Why?
George Sr.: Simple. We never talk about it.
Sheldon: So you just avoid discussing topics you don't agree on?
George Sr.: At all costs.

Meemaw: I bowled a new high score last night.
George Sr.: Nice.
Meemaw: I got two turkeys.
Missy: What's a turkey?
Meemaw: It's three strikes in a row.
Missy: Why do they call it a turkey?
Meemaw: Well, when they first invented bowling, they used to just throw frozen turkeys at the pins. Eventually, they switched to balls to cut down on the smell.
George Sr.: Why you lying to her?
Meemaw: I find it keeps my mind sharp.

Adult Sheldon: Like a virus, heartbreak can also spread. Once it does, it's hard to contain. In some cases you can try to reboot and start over. But it makes you appreciate those early days, when your hard drive was clean... and the world was full of possibility.

Meemaw: Well, let's get into it. What happened? If it's another woman, she's a tramp, and you're way prettier.
Brenda Sparks: No. Although sometimes I wish there was. Then I'd have someone to be mad at other than myself.
Meemaw: And here I thought this one was gonna be the sad sack.
Mary: Mom, that is enough.
Meemaw: Oh, there's my little killjoy. [both laughing]

Adult Sheldon: As long as humans have been on Earth, they've had to contend with viruses. And as long as I've been on Earth, I've come up with fun ways to avoid them.
[flashback:]
Dr. Linkletter: I've heard so much about you. [offers hand]
Sheldon: Apparently not how I feel about shaking hands.
Adult Sheldon: I wear personal protective equipment...
[flashback to Sheldon putting on mittens at the dinner table]
[flashback to Sheldon wearing an astronaut suit in his bubble:]
Mary: You come here right this instant.
Adult Sheldon: ...and I was social distancing before it was cool. But in the early '90s, a new type of virus became prevalent. One that no amount of hand-washing could stop. A computer virus.
Sheldon: Oh, no.
Adult Sheldon: But let's back up and begin this story in a simpler time, before an insidious infection had upended my life.