Mary: What's going on?
Sheldon: I can't do it.
Mary: What's wrong?
Sheldon: What if there's another crash?
Mary: Baby, that's not gonna happen again.
Sheldon: You don't know that.
Mary: Sheldon, if you don't get in right now, you're going to miss school.
Sheldon: [sighs] True. [enters car]
Mary: I know you don't believe in it, but I'm gonna say an extra special prayer right now to keep us safe. Lord, please look after me and Sheldon on our drive to school... [door opens] [sighs] I'll get back to you.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: My mother eventually coaxed me back into a car with a trip to RadioShack. She knew I was nervous so she came up with an interesting distraction.
Mary: Baby, how about we play a car game?
Sheldon: I suppose. Can I make it science-based?
Mary: Sure.
Sheldon: I'll say an element starting with "A," then you repeat that and add one starting with "B."
Mary: I don't think I'll get very far.
Sheldon: Great. Then I'll win. Aluminum.
Mary: Okay, uh, you said "A" for aluminum. "B." Is boron an element?
Sheldon: Yes.
Adult Sheldon: It was the beginning of a new tradition. One that would eventually bring countless hours of joy to Leonard on our drives to work. Much like my mother, he never beat me.
Mary: I don't know an element that starts with "D."
Sheldon: I win. That was fun. Round two. Argon.

Dr. John Sturgis: [on the phone] So, there's no one who can lend you a car?
Meemaw: There is the church shuttle, but that just feels like it's the end of the line.
Dr. John Sturgis: Oh, I wouldn't say that. There's all sorts of depressing steps before the end. You've got full-time nursing care.
Meemaw: Bye, John.
Dr. John Sturgis: Assisted living.
Meemaw: Bye, John.
Dr. John Sturgis: Hospice.
Meemaw: Bye, John.
Dr. John Sturgis: Life support.
Meemaw: Bye, John!
Dr. John Sturgis: Pulling the plug. [chuckles]
Meemaw: Bye, John.
Dr. John Sturgis: Then... you make a miraculous recovery!
Meemaw: Great!
Dr. John Sturgis: But... the hospital bills leave you destitute!
Meemaw: Bye.
Dr. John Sturgis: Bye.

Dr. John Sturgis: [on the phone] Oh, my goodness. Was anyone hurt?
Meemaw: No. But now I got no car for a while.
Dr. John Sturgis: You could ride your bike.
Meemaw: An old lady on a bike? That's not cool.
Dr. John Sturgis: Really? Then I won't ask how I look on one.
Meemaw: You look great.
Dr. John Sturgis: I know. I just wanted to hear you say it. [Meemaw chuckles]