Mary: [on the phone] Hold on. You're not gonna be around when Sheldon starts college?
Dr. John Sturgis: That's a great question. No.
Mary: John, I agreed to let him go because you were gonna be there to look after him.
Dr. John Sturgis: I know. And I feel terrible about it, but... please understand, this is a once-in-a-lifetime opportunity. I couldn't turn it down.
Mary: Orientation starts next week.
Dr. John Sturgis: I'm aware.
Mary: [sighs] Well, I hope that you're ready to hear him freak out when you tell him.
Dr. John Sturgis: I was kind of hoping he'd just be excited I get to work on the supercollider.
Mary: Right, because being happy for other people is where he shines.
[cut to:]
Sheldon: [on the phone with John] A supercollider? Well, you can't say no to that.
Mary: I give up.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Billy Sparks: Who's Melissa?
Missy: Me.
Billy Sparks: Then who's Missy?
Missy: "Missy" is short for "Melissa." Like how "Billy" is short for "William."
Billy Sparks: I don't understand.
Missy: You know how your real name is William?
Billy Sparks: I'm Billy.
Sheldon: No, we call you Billy, but your real name is William.
Billy Sparks: But my underpants say "Billy" in them. Mom, is my name William?
Brenda Sparks: [sighs] Yeah.
Billy Sparks: Then whose underpants am I wearing?

Sheldon: I may not look it, but I'm the future of physics, so just move on.

Pastor Jeff: Two months! Two months till this baby comes! There's so much I thought I was gonna do in my life.
George Sr.: I'm sure you've done plenty.
Pastor Jeff: Nothing cool. Look at you. You played football and rode a motorcycle.
George Sr.: Well, you save people's souls. That's neat, right?
Pastor Jeff: Oh, it's neat as neat can be, but you know that's not what I'm talking about.
George Sr.: [sighs] Look, being a dad doesn't mean your life is over. It just means it's different. Instead of playing football, I get to coach it now. I mean, high school football. Not college like I'd hoped. I-Instead of a motorcycle, I drive a truck. To work every single day. To pay the bills. [sighs] Oh. Endless bills. What happened to my life?
Pastor Jeff: Orange wedge?