Mary: [on the phone] Hold on. You're not gonna be around when Sheldon starts college?
Dr. John Sturgis: That's a great question. No.
Mary: John, I agreed to let him go because you were gonna be there to look after him.
Dr. John Sturgis: I know. And I feel terrible about it, but... please understand, this is a once-in-a-lifetime opportunity. I couldn't turn it down.
Mary: Orientation starts next week.
Dr. John Sturgis: I'm aware.
Mary: [sighs] Well, I hope that you're ready to hear him freak out when you tell him.
Dr. John Sturgis: I was kind of hoping he'd just be excited I get to work on the supercollider.
Mary: Right, because being happy for other people is where he shines.
[cut to:]
Sheldon: [on the phone with John] A supercollider? Well, you can't say no to that.
Mary: I give up.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Pastor Jeff: And now George's loving wife Mary would like to say a few words. Mary.
Mary: Thank you, Pastor Jeff. Um... [clears throat] I met George in high school. Well, I was in high school. He was an older man with a motorcycle. [light laughter] I'd like to tell you he caught my eye, but actually it was the motorcycle. [laughter] [voice breaking] I'm sorry, I can't... do this. I am... so angry. [sighs] George and I had our ups and downs, but we were finally in such a good place, and then he... left. [crying] He left all of us. I- How could you do that? [Meemaw stands up] I am so mad at him. I'm mad at God, I'm mad at myself for not trying harder while he was here. [Meemaw goes up to Mary] This wasn't supposed to happen. [Mary sobs] [Meemaw hugs Mary] [Georgie hugs a crying Missy]

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Billy Sparks: Who's Melissa?
Missy: Me.
Billy Sparks: Then who's Missy?
Missy: "Missy" is short for "Melissa." Like how "Billy" is short for "William."
Billy Sparks: I don't understand.
Missy: You know how your real name is William?
Billy Sparks: I'm Billy.
Sheldon: No, we call you Billy, but your real name is William.
Billy Sparks: But my underpants say "Billy" in them. Mom, is my name William?
Brenda Sparks: [sighs] Yeah.
Billy Sparks: Then whose underpants am I wearing?

Sheldon: I'm excited to finally use college-ruled paper and not feel like I'm living a lie.
Billy Sparks: What's college-ruled paper?
Sheldon: The lines are 18% closer together.
Billy Sparks: College sounds hard.
Brenda Sparks: You won't have to worry about that, honey.
Billy Sparks: Okay.

Dr. John Sturgis: [on answer machine] Hello, Coopers. Dr. Sturgis here. This is a message for Mary. I have some news I need to share with you before Sheldon starts college. Please call me back. [answering machine beeps]
Sheldon: I wonder why he'd want to talk to you and not me.
Dr. John Sturgis: [answering machine beeps] Dr. Sturgis again. If Sheldon happened to hear that last message and is wondering why I'd want to speak to his mother first and not him... Excellent question! It's that kind of curiosity that makes him a true man of science. [answering machine clicks, beeps]
Sheldon: I'm a true man of science.