George Sr.: What do you got going on today?
Mary: Ooh, laundry, grocery shopping, vacuuming. I might go nuts and dust the picture frames.
George Sr.: Well, nice. Everybody's doing something they love.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: Presenting... "Sheldon Cooper's Top Five Sources of News From My Childhood". Number five: Star Trek Fan Club Magazine.
Sheldon: Mom, DeForest Kelley's favorite episode is "The Empath."
Mary: Good to know.
Adult Sheldon: Number four: the Weather Cube from RadioShack.
Man: [from device] The humidity is 90% with a dew point of 79.5 degrees.
Sheldon: Mom! The dew point is 79.5 degrees.
Mary: [o.s.] Okay.
Adult Sheldon: Number three: The MacNeil/Lehrer NewsHour. Such a great theme song.
Sheldon: [hums] Buh-buh-bum.
Adult Sheldon: Number two: Meemaw after a few beers.
Meemaw: It took a while, but we finally picked a new name for my bowling team: The Ball Busters.
Sheldon: Hey, Mom. Guess what Meemaw named her bowling team? The Ball...
Adult Sheldon: And the number one source of news from my childhood: the bulletin board at the train store. News about trains in a store full of trains. Yummy.
Sheldon: How did this not make The MacNeil/Lehrer NewsHour?

Meemaw: Alls I'm saying is people aren't always in the mood.
Sheldon: Well, they should be. I'm happy to learn any fact at any time.
Meemaw: Is that so?
Sheldon: Yes.
Meemaw: Grab my knitting bag.
Sheldon: I don't recommend driving while knitting. Your reflexes aren't what they used to be.
Meemaw: Just look in the bag! Did you know that there are three different kinds of yarn?
Sheldon: I didn't.
Meemaw: You got your animal, like wool. Your plant, like cotton. And your synthetic, like acrylic.
Sheldon: Interesting.
Meemaw: You think so? I'm glad to hear that. Because each one of them has plusses and minuses, and you're about to hear them all in mind-numbing detail.

Mary: [eating pop corn] Get him, Dalton. Get him.
George Jr.: Mary Cooper, what are you doing?
Mary: Nothing.
George Jr.: Why are you watching Road House?
Mary: Why aren't you at work?
George Jr.: I asked you first, and my question is way more interesting.
Mary: It was just on. I don't even know what that is.
George Jr.: Then how'd you know his name's Dalton?
Mary: I don't have to explain myself to you.
George Jr.: This is a pretty dirty movie.
Mary: How do you know? It is rated R.
George Jr.: For violence, language and sexual content. You should be ashamed of yourself.