Mary: I brought you a snack.
Missy: Thanks.
Mary: So, I don't know if you heard me and your father having a disagreement last night...
Missy: A "disagreement"?
Mary: Fine. A spat. Okay, a fight. I just want you to know that you do not need to worry.
Missy: It's kind of hard not to.
Mary: Uh, sometimes moms and dads have fights, but it doesn't mean that they don't work things out.
Missy: Did you work it out?
Sheldon: [o.s.] We're home.
Mary: Eat your cookies.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: Shelly and this college stuff is killing me. I... I never went to college. How can I prepare him?
Brenda Sparks: Mary, if that kid is smart enough to have colleges wanting him already, he's got to be smart enough to figure it out.
Mary: Maybe. It still hurts to hear him say he wants to leave.
Brenda Sparks: I bet. On the other hand, I'm worried my Billy will never be ready to leave.
Mary: Oh, of course he will.
Brenda Sparks: Damn. Smoking, drinking, lying. You're covering all the sins today.

Mary: So, George is mad at me, and Sheldon is mad at me, and... honestly, I'm mad at me, too.
Brenda Sparks: Will you please give yourself a break? All that you do for that family, I am surprised you didn't crack years ago.
Mary: How do you handle it all?
Brenda Sparks: I'm sitting in a chicken coop drinking a wine cooler at 11:00 a.m.... clearly, I don't.

[on the "Why Sheldon Cooper Should Go to College" tape:]
Ms. Ingram: Honestly... teaching Sheldon is the hardest thing I've ever had to do. And I don't say that because he can be a pain. I say that because he's so intelligent, I had to study every night just to keep up. I'm gonna miss him.