George Jr.: If you're gonna do this, let me give you some pointers.
Sheldon: You've done this before?
George Jr.: Tell him.
Missy: Oh, he's the master. He coached me through my last two sore throats.
Sheldon: I slept on the couch during those.
Missy: I know.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: The following day, I returned to school. I had no choice but to fulfill my swimming requirement. Much like Batman, I suited up and faced my fears. Unlike Batman, I did it with a doggy-paddle across the shallow end of the pool. Uh, regarding pool sanitation, it turned out I was right. It was teeming with germs. Only I was the one who put them there. As it happens, my interaction with Billy Sparks did get me sick. I, in turn, created a small epidemic taking down 128 students, four teachers and one principal. It didn't stop there. I also infected my mother, father, sister, brother, Meemaw and Meemaw's friend Dale. The newly established boundaries of friendship helped keep Dr. Sturgis healthy. However, in an unrelated incident, he crashed his bike into some garbage cans. Luckily, he landed on his recently acquired athletic cup.
Dr. John Sturgis: That was a wise purchase.

Adult Sheldon: In many ways, a high school is like an academic house of horrors. There's the cafeteria, which when even freshly cleaned, maintains a subtle aroma of tater tots and throw-up. The schoolyard, where one is exposed to bullying by delinquents and attacks from above by eye-pecking demons. [bird tweets] But all of these pale in comparison to the most horrific location of all. A place teeming with the sweat and secretions from hundreds of unwashed bodies. The swimming pool.

Principal Petersen: Sorry, Sheldon. Water safety is a required part of your P.E. class.
Sheldon: But other kids use that pool. It's basically a big bowl of teenager soup.
Principal Petersen: It's out of my hands. It's a state requirement. If you don't like it, take it up with your congressman.
Sheldon: I did. He won't return my calls.
Principal Petersen: Then I guess you're swimming tomorrow. [manic laughter, thunder clap and lightning]
Adult Sheldon: Except for the laughter, the glowing eyes and the lightning, that's exactly how it happened.