Mary: She can cut her own crusts off.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Billy Sparks: Hello.
Herschel Sparks: Hey.
George Sr.: Hey, Billy.
Billy Sparks: Was this fence window always here?
Herschel Sparks: No, son, that's a new fence window.
Billy Sparks: Anybody else getting dizzy?

Sheldon: How do we love our neighbors when our moms hate each other?
Billy Sparks: Who does your mom hate?
Sheldon: Your mom.
Billy Sparks: Hey, my mom hates your mom. Small world.

Brenda Sparks: Well, I'm sorry, but you shouldn't be inferring there's something wrong with my Billy.
Meemaw: Darlin', there's no inferring. I've seen the boy sitting in the dirt eating his own belly button lint.