Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Mary: All right, Tam. I decided I was gonna make you a real Texas dinner. Barbecued chicken and brisket.
Tam: Thank you.
Mary: Well, I figured you were probably tired of stuff wiggling around on your plate.

Adult Sheldon: As you can see, sometimes a person can be both incredibly intelligent and full of baloney.

Adult Sheldon: Anger is an ugly emotion. Unbridled rage even more so. And when it bubbled up inside me, I channeled it the only way I knew how. I cleaned the house like a man possessed.

Mary: You smoke marijuana?
Sheldon: Mom!
Libby: No, ma'am.
Tam: Just say no. [Mary shoots him an unimpressed look]