[future:]
Amy Farrah Fowler: I would love to dissect your brain to see which part is missing.
Adult Sheldon: Or you'll find an all-new structure no one's ever seen before, an evolutionary leap forward.
Amy Farrah Fowler: Don't push me, I have a bone saw. [exits]
Adult Sheldon: All these years, and the passion is still there.

Adult Sheldon: I didn't realize until years later that my father was only asking questions about lightning and thunder to cheer me up. In fact, he would often pretend to be dumb just to make me feel better.

Adult Sheldon: My father didn't always get the credit he deserved. The advice he gave me actually worked out pretty well. Of course, I never told him.
George: Talked to Billy.
Missy: Why would you do that?
George: No, it was good.
Missy: Stay out of my life.
Adult Sheldon: He may not have been the world's greatest dad. But maybe we weren't the world's greatest kids.

Adult Sheldon: Ignoring things that irritate me isn't my strong suit. Obsessively fixating on them, now that's what gets me out of bed in the morning.

[Adult Sheldon walks through his childhood home:]
Adult Sheldon: Eventually, my mom sold the house. My dad's chair was gone. My spot was gone. [sits down on couch] Where we ate together. But I can still remember it exactly the way it was the day I left for Caltech.
Missy: Hey.
[Young Sheldon turns around to face Missy]
Missy: What are you doing?
Sheldon: Taking it all in one last time, so I remember it when I'm older.
Missy: You gonna remember me?
Sheldon: I have an eidetic memory. I have no choice.
Missy: Ha.

Pastor Jeff: Okay, now our next baptism is for Sheldon Lee Cooper, our soon-to-be brother in Christ. And, personally, this is a big get for me.

Mary: Are you gonna go, too? I know you don't believe.
Sheldon: I don't. But I believe in you.
Mary: Thank you.