George Sr.: Oh, come on. You're making it out like they were some kind of monsters. Sheldon has his own room. There's books everywhere. Even has a big old backyard he won't play in.
Mary: Aren't you forgetting somethin'?
George Sr.: What?
Mary: The underground laboratory.
George Sr.: I think it's called a finished basement, honey.
Mary: I know what I saw.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Ms. MacElroy: Tell you what I do. I send him on little errands. Like the other day, I told him, "Go to the supply room and get me a framastan."
Coach Wilkins: What's a framastan?
Ms. MacElroy: No such thing. I made it up. He was gone the whole period.
Ms. Ingram: [laughs] I'm using that.
Ms. MacElroy: Don't use framastan. That's mine.

Meemaw: You sure you're not jealous 'cause your little brother's moving up in the world?
George Jr.: Hey, I got plans of my own.
Meemaw: Do tell.
George Jr.: Soon as I graduate high school, I'm gonna be a professional male model.
Meemaw: That is hilarious.
George Jr.: What? I'm good-lookin'.
Meemaw: No, that you think you'll graduate high school.
Missy: The model thing was funny, too.

Adult Sheldon: As you can see, even as a small child, people cherished having me around and wept over my absence.