Sheldon: How does the future not concern you?
Missy: I guess there's stuff I'm looking forward to.
Sheldon: Like what?
Missy: Going on dates?
Sheldon: Boring.
Missy: Driving.
Sheldon: Scary.
Missy: Getting married. Hopefully to Vanilla Ice.
Sheldon: You want to marry a snow cone?

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Dr. Sandra Thorpe: Have you always been that way?
Missy: I guess so. I think when you're on your own a lot, you get good at seeing that kind of stuff.
Dr. Sandra Thorpe: Really?
Missy: My dad does football with my older brother, so they're like a team. And my mom and meemaw spend all their time fussing over Sheldon, so they're like a team, too.
Dr. Sandra Thorpe: So no one's on your team?
Missy: Nope. It's just me.

Adult Sheldon: [hushed] This is why the only bar I frequent is the Genius Bar at the Apple Store.

President Hagemeyer: Okay, so, what's the problem?
Sheldon: I wanted to talk with Dr. Linkletter about puberty.
Dr. Linkletter: And I wanted to avoid litigation.

Missy: Sheldon, there has to be stuff you're excited to do.
Sheldon: Of course. Getting my PhD, winning the Nobel Prize, getting to meet Professor Proton, working with Stephen Hawking.
Missy: Okay, so, when you start to get upset, focus on that stuff.
Sheldon: But... what if I grow up and none of those things ever happen?
Missy: All you can do is try and find out.
Sheldon: Those are the fundamentals of the scientific method.
Missy: No doy.