Sheldon: How does the future not concern you?
Missy: I guess there's stuff I'm looking forward to.
Sheldon: Like what?
Missy: Going on dates?
Sheldon: Boring.
Missy: Driving.
Sheldon: Scary.
Missy: Getting married. Hopefully to Vanilla Ice.
Sheldon: You want to marry a snow cone?

Missy: Eat dirt. Eat it.
Meemaw: Kick his ass!
Missy: Does it taste good? Huh?
Dale: Yeah, listen to your meemaw. Kick his ass!
Missy: You gonna cry? Huh? Do it. Cry.
Mary: Do something. Break it up.
George Sr.: H-Hang on. She's winning.
Mary: Missy! Missy Cooper, you stop beating up that boy!
Meemaw: Punch him in the nuts!

Missy: Someone's Underoos are in a knot.
Sheldon: My Underoos are fitting just fine, thank you.
Missy: Then why is there a stick up your butt?
Sheldon: Stop making inquiries about my bottom.
Missy: But I enjoy it.

[Sheldon sits on the top of the couch with his feet on the cushion]
Missy: What are you doing?
Sheldon: I'm practicing the philosophy of cynicism... The ancient Greek view that the rules of society should be ignored.
Missy: If you're gonna break rules, you can do better than that.
Sheldon: How?
[Missy pushes Sheldon off the couch]

Adult Sheldon: [hushed] This is why the only bar I frequent is the Genius Bar at the Apple Store.

President Hagemeyer: Okay, so, what's the problem?
Sheldon: I wanted to talk with Dr. Linkletter about puberty.
Dr. Linkletter: And I wanted to avoid litigation.

Missy: Sheldon, there has to be stuff you're excited to do.
Sheldon: Of course. Getting my PhD, winning the Nobel Prize, getting to meet Professor Proton, working with Stephen Hawking.
Missy: Okay, so, when you start to get upset, focus on that stuff.
Sheldon: But... what if I grow up and none of those things ever happen?
Missy: All you can do is try and find out.
Sheldon: Those are the fundamentals of the scientific method.
Missy: No doy.