George Sr.: What do you mean you quit?
Sheldon: It was beneath me.
George Sr.: You need to learn there's nothing wrong with a little hard work.
Sheldon: Hard work is calculating neutrino properties to one percent accuracy. Anyone can wash bolts.
George Sr.: You begged him for that job.
Sheldon: I assumed he'd realize the value of my intellect and put it to good use.
George Sr.: Hang on. You made a commitment. When you say you're gonna do something, you do it.
Sheldon: Well, he could find someone else.
George Sr.: Doesn't matter. This is about you being a man of your word.
Adult Sheldon: I wanted to point out that I couldn't be a man of my word, since I hadn't hit puberty, but he seemed pretty grouchy.

George Sr.: And Sheldon's fine. You know what he's like. If someone took him, I'm sure they'll bring him right back.

Sheldon: Dad, do you believe that fossils are millions of years old?
George Sr.: I guess. Why?
Sheldon: Well, Mom believes the world was only created 6,000 years ago.
George Sr.: Yeah. So?
Sheldon: Are these differences a sticking point in your marriage?
George Sr.: Not at all.
Sheldon: Why?
George Sr.: Simple. We never talk about it.
Sheldon: So you just avoid discussing topics you don't agree on?
George Sr.: At all costs.

Meemaw: I bowled a new high score last night.
George Sr.: Nice.
Meemaw: I got two turkeys.
Missy: What's a turkey?
Meemaw: It's three strikes in a row.
Missy: Why do they call it a turkey?
Meemaw: Well, when they first invented bowling, they used to just throw frozen turkeys at the pins. Eventually, they switched to balls to cut down on the smell.
George Sr.: Why you lying to her?
Meemaw: I find it keeps my mind sharp.

George Jr.: What is this?
Meemaw: That's the exercise guy Meemaw likes.
George Jr.: I can't believe anyone pays money to watch old people sweat.
Missy: 40 bucks?
George Jr.: They sold over a million of those? At 40 bucks a pop? Do you know how much money that must be?
Missy: I'm not a calculator.
[later:]
George Jr.: 40 times... one million. That's 40 million!
Missy: Whoa.

Adult Sheldon: Behind every great scientist, there were often unsung helpers toiling away in the background. Presenting... "Great Lab Assistants in Scientific History" When Alexander Graham Bell needed an assistant, it was Thomas Augustus Watson who answered the call. [laughs] Get it? "The call". [snickers] Madame Curie's daughter Irène was also her lab assistant. Irène was so dedicated, she died of radiation poisoning. Unlike her sister Ève, who selfishly lived to 102. Lastly, Émile Roux was assistant to Louis Pasteur. When they worked on the rabies vaccine, Roux kept a loaded gun in the lab to shoot Pasteur in the head if he got infected. He never had to, but it's fun to know he would have.
Dr. Linkletter: No, Sheldon. You can't be my lab assistant.
Sheldon: Maybe you weren't paying attention. I'll start over. Behind every great scientist, there was a dedicated as...

Adult Sheldon: While not the lab work I hoped to be doing, it did feel good to be part of an actual experiment. A tedious, menial part that could be performed by a monkey. Or worse, an engineer.