Keith: Someone's got to be in charge, but when you step up and do it, everyone gets upset.
George: So your problem is a woman's mad at you and Sheldon thinks you're dumb?
Keith: Yeah.
George: Welcome to my life, friend.
Keith: W- What do I do?
George: You- You quit complaining. You're young, you're smart, you're not tied down. This is as good as it gets.
Keith: It is?
George: Yes. I wish I was 20 again. Eating and drinking and being skinny. Now go back in there, finish your project, and get your ass to a keg party. Go!

George: And Sheldon's fine. You know what he's like. If someone took him, I'm sure they'll bring him right back.

Sheldon: There's going to be a lecture on carbon dating at the Natural Science Museum on Saturday. Who would like to take me?
George: You know what? I'd be happy to.
Meemaw: What happened to helping me at my yard sale?
George: Ooh, is that this Saturday? I'm sorry. I'm taking him to a lecture on, uh what is it? Carbonation?
Sheldon: Carbon dating. A method of determining the age of artifacts and fossils.
George: Hey, we could use that to figure out how old your grandma is.
Sheldon: That won't work. You can't carbon-date something that's alive.
George: Well, then, we'll just chop her down and count the rings.
Meemaw: Oh, George, did my "lump of clay" remark strike a nerve?
George: A little.

Georgie: A bill? Really?
George: Room and board, buddy.
Georgie: $50 a month for food?
George: The way you eat, I should've gone $50 a week.
Georgie: Laundry services?
George: Your poor mother has to touch your underwear.
Georgie: What's the $10 a month "peema" charge?
George: Oh, P-I-M-A, that's a "Pain in My Ass" tax. My way of getting compensated for you taking years off my life.

Meemaw: All right, come on, let's talk about something else.
June: Okay.
Dr. John Sturgis: A lot of people here like to talk about the game.
Meemaw: Really? You speak sports now?
Dr. John Sturgis: I sure do. Check this out. Hey, ref! I suggest you go back to referee school and this time pay attention in class!
Man #1: You tell him, Doc.

Mary: How about you all come work at our house?
Sam: I guess if that's our only option.
Mary: It'll be fun. I'll make food. You can even bring your laundry.
Keith: That actually would be great.
Sheldon: Now this man's soiled underpants will be in my kitchen. Thank you.

Keith: How about we work in my dorm tomorrow?
Mary: Um, I don't know if a dormitory is the right environment for someone his age.
Sheldon: If you're worried about the beer-drinking, Dad has thoroughly desensitized me.