Meemaw: So what do you think, George? Is it time to have "the talk" with him?
Missy: What talk?
Mary: No talk. Nobody's talking.
Sheldon: If "the talk" is in regards to human reproduction, I already understand how that works.
Mary: How do you know that?
Missy: I told him.
Mary: Oh, Lord.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Adult Sheldon: As you can see, sometimes a person can be both incredibly intelligent and full of baloney.

Adult Sheldon: Anger is an ugly emotion. Unbridled rage even more so. And when it bubbled up inside me, I channeled it the only way I knew how. I cleaned the house like a man possessed.

Mary: You smoke marijuana?
Sheldon: Mom!
Libby: No, ma'am.
Tam: Just say no. [Mary shoots him an unimpressed look]