Wendy: This is... just a pimple.
Sheldon: Well, how can you be sure it isn't chickenpox? Or smallpox? Or monkeypox, which I know sounds made-up, but is very real.
Wendy: Have you been near any monkeys?
Sheldon: No.
Wendy: Try benzoyl peroxide. It's over the counter.
[fantasy: A.V. and Pus:]
A.V.: Oh, no, not... benzoyl peroxide. [high-pitched] I'm melting! I'm melting! [normal voice] Give me a break.
[reality:]
Sheldon: But a pimple is a sign of puberty, and I'm showing no other indicators. No armpit or chest hair, and I have so little interest in the opposite sex, I barely noticed you're a woman.
Wendy: Thank you.

Ms. MacElroy: Now, can anyone tell me why Melville shifts the narrative voice from Ishmael to Ahab? [Ms. MacElroy waits for somebody else to raise their hand] Sheldon.
Sheldon: I have a tummyache. I'd like to see the nurse.
Derek: A "tummyache"?
Sheldon: Yes, Derek, I have a tummy and it aches. Ergo, tummyache.
Derek: "Ergo"?
Sheldon: It's Latin, Derek.
Ms. MacElroy: Go to the nurse.
Sheldon: And to answer your question, the shifting point of view grants the reader a broader perspective of events than typically allowed by first-person narration.
Ms. MacElroy: Where were we?
Sheldon: And "ergo" is Latin for "hence," Derek.

Pastor Jeff: Come on up here, Sheldon. Let's hear what you got.
Sheldon: I've spent the last week studying what people believe, and I've come to a conclusion.
Pastor Jeff: And what's that?
Sheldon: I'm starting my own religion.
Pastor Jeff: I'm sorry, what?
Sheldon: I'm calling it Mathology. It's based on a universal binary system.
Pastor Jeff: That's terrific, Sheldon, but this is a Baptist Sunday school.
Sheldon: I know, I'm here to convert everybody. Any takers?
Pastor Jeff: Okay. Let's go have a talk with your mom.
Sheldon: The only sin in Mathology is being stupid.

Mary: Too bad. We are going.
Sheldon: Class is starting tomorrow. I'm not going anywhere.
Mary: Sheldon, do not argue with me. You are going home.
Sheldon: Mom, the people of Germany are obsessed with rules and devoid of humor. I am home.

Adult Sheldon: [hushed] This is why the only bar I frequent is the Genius Bar at the Apple Store.

President Hagemeyer: Okay, so, what's the problem?
Sheldon: I wanted to talk with Dr. Linkletter about puberty.
Dr. Linkletter: And I wanted to avoid litigation.

Missy: Sheldon, there has to be stuff you're excited to do.
Sheldon: Of course. Getting my PhD, winning the Nobel Prize, getting to meet Professor Proton, working with Stephen Hawking.
Missy: Okay, so, when you start to get upset, focus on that stuff.
Sheldon: But... what if I grow up and none of those things ever happen?
Missy: All you can do is try and find out.
Sheldon: Those are the fundamentals of the scientific method.
Missy: No doy.