Mary: Shelly, remember when you thought you had leprosy, and it was just a patch of dry skin?
George: And when you thought you had gout? Or an enlarged prostate?
Mary: Or mad cow?
Missy: That was my favorite.

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Sheldon: While Dad's gone, I'm the man of the house, and the man of the house has to enforce the rules.
Missy: The man of the house is about to get his teeth knocked out.
Sheldon: Puberty's made you mean.
Missy: I need to know what happened on my show.
Sheldon: And you'll find out when your privileges are restored.
Missy: I can't wait that long, each episode builds on the last. Imagine a Star Trek that ends with "to be continued," and you don't get to continue.
Sheldon: That would never happen, because I follow the rules.
Missy: You are this close to a purple nurple.
Sheldon: [covers nipples] You leave my nurples alone.

Meemaw: So I saw a lawyer today.
Mary: Why?
Meemaw: I'm putting together my last will and testament.
George: We're gonna miss ya.
Mary: George.
Meemaw: Don't worry. I ain't leaving him squat.

Mary: Sheldon, who are you talking to?
Sheldon: Dorothy Fitzpatrick.
Mary: Who's Dorothy Fitzpatrick? Is she a new buddy from school?
Sheldon: She's the loan officer at The First National Bank of Medford.
Mary: Why are you talking to her?
Sheldon: Mom, can this wait? I'm trying to negotiate favorable terms. Hello, Dorothy? [Mary hangs up]

Adult Sheldon: People often wonder why I chose to pursue a career in theoretical physics. I usually respond by saying I wanted to unravel the inner workings of the universe. But the real answer was I wanted to prove this nincompoop wrong.