Missy: I feel like this cover really says who I am now.
Sheldon: That looks like all your notebooks.
Missy: Missy got ponies. Melissa gets horses.

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Sheldon: While Dad's gone, I'm the man of the house, and the man of the house has to enforce the rules.
Missy: The man of the house is about to get his teeth knocked out.
Sheldon: Puberty's made you mean.
Missy: I need to know what happened on my show.
Sheldon: And you'll find out when your privileges are restored.
Missy: I can't wait that long, each episode builds on the last. Imagine a Star Trek that ends with "to be continued," and you don't get to continue.
Sheldon: That would never happen, because I follow the rules.
Missy: You are this close to a purple nurple.
Sheldon: [covers nipples] You leave my nurples alone.

Billy Sparks: Who's Melissa?
Missy: Me.
Billy Sparks: Then who's Missy?
Missy: "Missy" is short for "Melissa." Like how "Billy" is short for "William."
Billy Sparks: I don't understand.
Missy: You know how your real name is William?
Billy Sparks: I'm Billy.
Sheldon: No, we call you Billy, but your real name is William.
Billy Sparks: But my underpants say "Billy" in them. Mom, is my name William?
Brenda Sparks: [sighs] Yeah.
Billy Sparks: Then whose underpants am I wearing?

Sheldon: I'm excited to finally use college-ruled paper and not feel like I'm living a lie.
Billy Sparks: What's college-ruled paper?
Sheldon: The lines are 18% closer together.
Billy Sparks: College sounds hard.
Brenda Sparks: You won't have to worry about that, honey.
Billy Sparks: Okay.

Dr. John Sturgis: [on answer machine] Hello, Coopers. Dr. Sturgis here. This is a message for Mary. I have some news I need to share with you before Sheldon starts college. Please call me back. [answering machine beeps]
Sheldon: I wonder why he'd want to talk to you and not me.
Dr. John Sturgis: [answering machine beeps] Dr. Sturgis again. If Sheldon happened to hear that last message and is wondering why I'd want to speak to his mother first and not him... Excellent question! It's that kind of curiosity that makes him a true man of science. [answering machine clicks, beeps]
Sheldon: I'm a true man of science.