Sheldon: I did it. Missy, I did it!
Missy: [groans] What?
Sheldon: I slept through the night.
Missy: What time is it?
Sheldon: 6:14.
Missy: This is why people hate you.
Adult Sheldon: My sister's crankiness did not dampen my enthusiasm. A chicken may have fractured my arm, but nothing could break my can-do spirit.

Sheldon: While Dad's gone, I'm the man of the house, and the man of the house has to enforce the rules.
Missy: The man of the house is about to get his teeth knocked out.
Sheldon: Puberty's made you mean.
Missy: I need to know what happened on my show.
Sheldon: And you'll find out when your privileges are restored.
Missy: I can't wait that long, each episode builds on the last. Imagine a Star Trek that ends with "to be continued," and you don't get to continue.
Sheldon: That would never happen, because I follow the rules.
Missy: You are this close to a purple nurple.
Sheldon: [covers nipples] You leave my nurples alone.

Brenda Sparks: You friends with this girl?
Missy: [scoffs] I wish. She is so popular. One time she said she liked my outfit... I wore it for a week.
Brenda Sparks: [scoffs] What am I gonna do? [both sigh]
Missy: You could tell Billy he's too young to date.
Brenda Sparks: [chuckles softly] That's good. You might be the coolest person in this house.
Missy: Low bar, but thanks.

Sheldon: Why would New Mutants be next to New Teen Titans?
Missy: Because they both start with "New"?
Sheldon: But one's Marvel and the other's DC. Would you put Aquaman and Sub-Mariner next to each other?
Missy: I don't know, they could talk about fish.

Meemaw: Look, you haven't even gotten to the worst part of it yet. They're gonna leave home. They're gonna move to another city.
Mary: Oh, Lord.
Meemaw: They're gonna tell you their loser boyfriend has knocked them up. Just to be clear, that would be you.
Mary: Sorry.
Meemaw: Turned my hair gray overnight.
Mary: I said sorry. Clearly, you're not in the mood to help.
Meemaw: Listen, it's hard being a parent, but if you do it right, they don't need you anymore.
Mary: Well, I don't like that. I get it, but I just don't like it.
Meemaw: Well, I'd point out, you'll always have your husband, but you want me to be "helpful".

Sheldon: This is bad.
George: You're gonna be just fine.
Sheldon: This is the arm I write with. This is the arm I eat with. This is the arm I do the Vulcan salute with. Ow.
George: It's not too swollen. That's a good sign.
Sheldon: You're not a doctor.
George: But I see this on the football field all the time.
Sheldon: Football players are meant to be hurt. I'm meant to be cherished.

Sheldon: Well, that's what I heard. And if Hawking doesn't let it stop him, then I can't let this cast stop me.
Missy: Great. Go back to sleep.
Sheldon: I will, and I'll do it all by myself. [sings] Soft kitty, warm kitty
Missy: Oh, my God.
Sheldon: Little ball of fur Happy kitty, sleepy kitty, purr Purr, purr.