Missy: I get it.
Sheldon: What do you get?
Missy: Why you don't want to go to college.
Sheldon: I doubt that you do.
Missy: You're scared everything's gonna be different and it'll be hard. And you're gonna miss the way that it was.
Sheldon: How do you know that?
Missy: 'Cause that's how I feel.
Sheldon: You're scared?
Missy: Yeah.
Sheldon: So what do we do?
Missy: I guess be scared and do it anyway.
Sheldon: Hmm. It's comforting to know that you feel the same way that I do.
Missy: That's why I said it, dumbass.

Mary: Missy, if you want a minute with Dad before they close the casket, now's the time. [Missy looks unsure] It's okay if you don't.
Mary: I have to. [Missy stands up and walks up to her father's casket]
[flashback:]
George: Here, let me help you with that. Okay.
Missy: [eats] Holy moly.
George: It's good, huh?
Missy: Unbelievable.
George: I'll leave you to it.
Missy: No, sit with me.
George: Okay.
[present:]
Missy: [crying] Thank you for that. Thank you for everything. [sniffles] I love you.

Sheldon: Is Mom okay?
George: How the heck should I know?
Missy: She left. You can say "hell."

Sheldon: While Dad's gone, I'm the man of the house, and the man of the house has to enforce the rules.
Missy: The man of the house is about to get his teeth knocked out.
Sheldon: Puberty's made you mean.
Missy: I need to know what happened on my show.
Sheldon: And you'll find out when your privileges are restored.
Missy: I can't wait that long, each episode builds on the last. Imagine a Star Trek that ends with "to be continued," and you don't get to continue.
Sheldon: That would never happen, because I follow the rules.
Missy: You are this close to a purple nurple.
Sheldon: [covers nipples] You leave my nurples alone.

Mary: So he's really good to graduate?
Principal Petersen: He sure is. I got to tell ya, usually when kids leave school after two years, it's not for college. It's for prison or pregnancy.
George: Well, between Georgie and Missy, we may hit the trifecta.
Mary: George!
George: Well, I'm not rooting for it. It's just a thing that could happen.

Principal Petersen: Our next young speaker needs no introduction, but that didn't stop him from writing one and making me read it. [laughter] "Fun fact." [audience groans, murmurs] I hear you. "The word 'valedictorian' is from the Latin 'valedicere,' meaning 'to say farewell.' It is primarily used in the United States, Canada, the Philippines and Armenia." Maybe that fact's more fun in Armenia. Please welcome your valedictorian, Sheldon Cooper.
Mary: Yay, Shelly!
Sheldon: Hello. I'm not very comfortable speaking in front of crowds. But there's a technique to reduce stage fright by focusing on one person in the audience and delivering your speech just to them. That's what I'll be doing today. If it weren't for this person, I wouldn't be here right now. They've taught me a lot, and it's by their example that I found the courage to move forward into this new and exciting chapter of my life. Missy... ...this is for you. Change can be scary, but I know we're going to be fine... ...because like you said, "It's okay to be scared. We just have to do it anyway." So if any of my fellow graduates are nervous about the future, know that you're not alone. I suggest you all try to be as brave as my twin sister. That's my plan. Missy, I wish I could give you advice about middle school, but I was so smart, I skipped it. If you make it to high school, we'll talk. Thank you. [applause]

Sheldon: Do you think I can make it from one end of the college campus to the other in under ten minutes, including a bathroom break?
Mary: I don't know. How important is the bathroom break?
Sheldon: Very. The class schedules are designed for fully-grown bladders, and mine is child-sized.
Mary: Then don't put your classes so close together.
Sheldon: Well, it's either this or I move my labs to Tuesday afternoons.
Mary: Is that bad?
Sheldon: Yes. That's when Professor Proton is on.
Mary: Well, we'll tape it, and you can watch it later.
Sheldon: But what if I have a lot of homework and can't get to it until the next day and one of the kids in my class spoils the episode for me?
Mary: Sheldon, has anyone ever spoiled Professor Proton for you?
Sheldon: No.
Mary: Has anyone even talked to you about Professor Proton?
Sheldon: Do you count?
Mary: No.
Sheldon: Then no.