Mary: [praying] Lord, I am trying my best. Please help me with this situation. Amen. [sees a "love thy neighbor" stitching on a pillow] I meant fix him, not me.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Pilot: [v.o.] Sorry for the delay. We hope to be wheels up in about 20 minutes.
Sheldon: That's what he said 20 minutes ago.
Mary: Nothing we can do.
Sheldon: If we don't take off soon, we'll miss our connecting flight to Houston.
Mary: It's out of our hands. I'd tell you whose hands it's in, but you don't like that.

Sheldon: Mark my words, string theory is going to be the next big thing.
Mary: What does it do?
Sheldon: It explains the fundamental forces of the universe. How everything works, where everything came from.
Mary: I know where it all came from. [points to the heavens]
Sheldon: Mother, we're in the sky. Why are you pointing up?

Ms. MacElroy: That's sweet of you for asking, but I'd rather stick my finger in a pencil sharpener and crank away.

Meemaw: What's up?
Missy: Can I talk to you about serious woman stuff?
Meemaw: Of course. Is this a... iced tea conversation or a hot tea conversation?
Missy: Definitely hot.
Meemaw: Uh-oh.

Sheldon: There's no telling who could buy that house! What if they have dogs? What if they have birds? What if they have both and the birds learned to bark like dogs?
Mary: Sheldon, you're gettin' yourself all worked up.
Sheldon: For good reason... that house is six feet away from my bedroom window. Who knows what kind of smells could jump the gap? Uh, cigarette smoke, a scented candle, a durian?
Mary: What's a durian?
Sheldon: A vile-smelling fruit of the genus Durio.
Mary: When did you smell that?
Sheldon: I haven't, and I'd like to keep it that way.
Mary: It might be nice. It might be a family with kids your age.
Sheldon: I already live with a kid my age... not a fan!