Sheldon: I've never been late to school before.
Missy: I'm late all the time. It's no big deal.
Mary: I get you to school on time every day. Why are you late?
Missy: I have a lot of people to say hi to in the morning.

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Adult Sheldon: Just like that, I overcame my fear of choking. All that was left was my fear of dogs, birds, insects, germs, hugging, button fly pants, rivers, ponds, lakes, oceans, estuaries, corduroy, root vegetables, squeaky balloons, tinted windows, take a penny, leave a penny, fireworks, potbelly stoves, dust bunnies, that fuzz on peaches.

George Sr.: And Sheldon's fine. You know what he's like. If someone took him, I'm sure they'll bring him right back.

George Sr.: If we take him to a shrink, it feels like we're admitting something's wrong with him.
Mary: He hasn't had solid food in five weeks.
Meemaw: Well, if there is something wrong with him, it ain't constipation.