Missy: What's a hackle?

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

Adult Sheldon: Dr. Sturgis was a wise man. It was a learning opportunity. And when the day comes that I'm wrong, I fully plan to admit it.

Ms. Hutchins: Sheldon, why aren't you in second period?
Sheldon: I'm working on this math problem.
Ms. Hutchins: I think you might be the first person in history who's ever cut class to do math.
Sheldon: The irony wasn't lost on me.

George Jr.: What's a math emergency?
George Sr.: That's when things don't add up. Oh, come on, guys. That was a good one.