Mary: Shelly, you okay?
Sheldon: No.
Mary: You want to talk about it?
Sheldon: No.
Mary: You want me to leave you alone?
Sheldon: No. I thought Libby and I were equals, but she thinks of me as a child.
Mary: I'm sorry, baby.
Sheldon: Calling me that isn't helping right now.
Mary: Right. Sorry.

Sheldon: Regardless, I'm not interested in making any more friends.
Mary: Oh, I don't think that's how you really feel.
Sheldon: It is. From now on, it's a hermit's life for me.
Mary: I bet, when you grow up, you will be surrounded by lots of smart, wonderful friends.
Sheldon: I can't see that happening.

Sheldon: Mom, when should I be expecting my testicles?
Woman: [turns around] What is wrong with him?
Mary: Nothing is wrong with him. Now turn around before I knock your lights out.
Sheldon: Hello.

Mary: Sheldon Lee Cooper, if you don't finish that pork chop, I swear I will chew it up and spit it in your mouth like a mama bird.
Missy: Do it, Mom. Do it.

Adult Sheldon: As you can see, sometimes a person can be both incredibly intelligent and full of baloney.

Adult Sheldon: Anger is an ugly emotion. Unbridled rage even more so. And when it bubbled up inside me, I channeled it the only way I knew how. I cleaned the house like a man possessed.

Mary: You smoke marijuana?
Sheldon: Mom!
Libby: No, ma'am.
Tam: Just say no. [Mary shoots him an unimpressed look]