George Sr.: Where you going?
Mary: I'm gonna give Sheldon a list of chores.
George Sr.: You're actually taking my advice?
Mary: Yes.
George Sr.: Well, how about that?
Mary: Hey, you were due.
Missy: Proud of you, George.

George Sr.: What are you doing?
Missy: Watching Sheldon struggle with homework. It's so great.

Missy: So, this Dr. Lee is turning your friends against you?
Sheldon: Essentially.
Missy: Classic move. Most girls you find crying in the school bathroom, that was it.
Sheldon: What do I do?
Missy: Well, you're in a tough spot 'cause your personality is ugh.
Sheldon: There's enough people being mean to me right now.
Missy: Sorry.
Sheldon: Can you help me or not?
Missy: It's you against a bunch of college professors. I don't think you can win this one. [Sheldon starts to walk away] Oh. Do any of them have pimples?
Sheldon: No.
Missy: Too bad, I've done a lot of damage with "pizza face."

Mary: Bless us, Lord, for the food we are about to receive and bless the hands that prepared it.
Missy: And bless Mom.
Mary: Thank you. Amen.
Missy: Amen.
George Jr.: Amen.
Sheldon: She's the hands that prepared it. Your blessing is redundant.
Mary: Let's eat.

George Jr.: I think the saddest part about it is just how sad it is.

Adult Sheldon: As you can see, my meemaw successfully lured me back into the world by reminding me of my brave Texas ancestors. Their blood ran through my veins. I was a true son of the Lone Star State. Albeit a true son with an incredibly fragile immune system. I woke up the next morning with a temperature of 102 and a head packed full of mucus.

Meemaw: Mind if I take a crack at catching the Road Runner?
Mary: What are you gonna do that I couldn't do?
Meemaw: Oh, a little trick I learned trying to get prairie dogs out of the hole. Of course we'd whack off their heads with a golf club. I'm not gonna do that to Sheldon.